Costimulatory and Inhibitory T-Cell Receptors; Flow Cytometry; T-Lymphocytes, Regulatory; Translational Medical Research; Transplantation; Transplantation Chimera; Transplantation Immunology; Transplantation Tolerance
My main research interest is the induction of donor specific transplantation tolerance to obviate the need for any immunosuppressive medication.
We focus on inducing tolerance through the transplantation of donor hematopoietic stem cells and the establishment of mixed chimerism (i.e. coexistence of donor and recipient hematopoietic cells in the host). This strategy leads to a particularly robust state of tolerance and has been demonstrated to work not only in rodents, but also in large animals (including non-human primates) and notably in pilot series of renal transplant recipients in the clinic.
Currently, I am specifically interested in the role of NK cells in tolerance induction and maintenance.