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Detail

Xaver König
DI Xaver König, PhD

Center for Physiology and Pharmacology (Division of Neurophysiology and Neuropharmacology)
Position: Research Associate (Postdoc)

ORCID: 0000-0002-2423-4966
T +43 1 40160 31232
xaver.koenig@meduniwien.ac.at

Keywords

Calcium; Cardiac Electrophysiology; Ion Channels; Muscle Fibers, Skeletal; Muscular Dystrophies; Pharmacology

Research interests

  1. Involvement of ion channels in the development and progression of cardiomyopathies in the context of muscular dystrophies
  2. Store-operated calcium entry in skeletal muscle
  3. Pharmacology of cardiac ion channels

Techniques, methods & infrastructure

  • electrophysiology,
  • confocal microscopy,
  • standard biochemistry,
  • induced pluripotent stem cells

Grants

  • Store-operated Calcium entry in skeletal muscle (2018)
    Source of Funding: FWF (Austrian Science Fund), Stand-alone project
    Principal Investigator
  • Cardiogenic agents (2009)
    Source of Funding: aws (Austria Wirtschaftsservice), PRIZE
    Principal Investigator

Selected publications

  1. Koenig, X. et al., 2011. Voltage-Gated Ion Channel Dysfunction Precedes Cardiomyopathy Development in the Dystrophic Heart M. Rota, ed. PLoS ONE, 6(5), p.e20300. Available at: http://dx.doi.org/10.1371/journal.pone.0020300.
  2. Koenig, X. et al., 2013. Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart. AJP: Heart and Circulatory Physiology, 306(4), pp.H564-H573. Available at: http://dx.doi.org/10.1152/ajpheart.00441.2013.
  3. Rubi, L. et al., 2018. Calcium current properties in dystrophin deficient ventricular cardiomyocytes from aged mdx mice. Physiological Reports, 6(1), p.e13567. Available at: http://dx.doi.org/10.14814/phy2.13567.
  4. Koenig, X., Choi, R.H. & Launikonis, B.S., 2018. Store-operated Ca2+ entry is activated by every action potential in skeletal muscle. Communications Biology, 1(1). Available at: http://dx.doi.org/10.1038/s42003-018-0033-7.
  5. Choi, R.H., Koenig, X. & Launikonis, B.S., 2017. Dantrolene requires Mg2+ to arrest malignant hyperthermia. Proceedings of the National Academy of Sciences, 114(18), pp.4811-4815. Available at: http://dx.doi.org/10.1073/pnas.1619835114.