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Detail

Xaver König
DI Xaver König, PhD

Center for Physiology and Pharmacology (Division of Neurophysiology and Neuropharmacology)
Position: Research Associate (Postdoc)

ORCID: 0000-0002-2423-4966
T +43 1 40160 31232
xaver.koenig@meduniwien.ac.at

Keywords

Calcium; Cardiac Electrophysiology; Ion Channels; Muscle Fibers, Skeletal; Muscular Dystrophies; Pharmacology

Research interests

  1. Involvement of ion channels in the development and progression of cardiomyopathies in the context of muscular dystrophies
  2. Store-operated calcium entry in skeletal muscle
  3. Pharmacology of cardiac ion channels

Techniques, methods & infrastructure

  • electrophysiology,
  • confocal microscopy,
  • standard biochemistry,
  • induced pluripotent stem cells

Grants

  • Cardiogenic agents (2009)
    Source of Funding: aws (Austria Wirtschaftsservice), PRIZE
    Principal Investigator

Selected publications

  1. Koenig, X. et al., 2011. Voltage-Gated Ion Channel Dysfunction Precedes Cardiomyopathy Development in the Dystrophic Heart M. Rota, ed. PLoS ONE, 6(5), p.e20300. Available at: http://dx.doi.org/10.1371/journal.pone.0020300.
  2. Koenig, X. et al., 2013. Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart. AJP: Heart and Circulatory Physiology, 306(4), pp.H564-H573. Available at: http://dx.doi.org/10.1152/ajpheart.00441.2013.
  3. Koenig, X. et al., 2012. Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk. Addiction Biology, 19(2), pp.237-239. Available at: http://dx.doi.org/10.1111/j.1369-1600.2012.00447.x.
  4. Thurner, P. et al., 2013. Mechanism of hERG Channel Block by the Psychoactive Indole Alkaloid Ibogaine. Journal of Pharmacology and Experimental Therapeutics, 348(2), pp.346-358. Available at: http://dx.doi.org/10.1124/jpet.113.209643.
  5. Choi, R.H., Koenig, X. & Launikonis, B.S., 2017. Dantrolene requires Mg2+to arrest malignant hyperthermia. Proceedings of the National Academy of Sciences, 114(18), pp.4811-4815. Available at: http://dx.doi.org/10.1073/pnas.1619835114.