Donor characteristics

Manually microdissected unstained glomeruli from a wedge transplant kidney biopsy (print magnification 200x)

Significant features. TI CAD vs LIV (p<0.05)

Unsupervised hierarchical clustering of LIV vs CAD microdissected glomeruli and tubuli.

Significant genes separating TI from G (SD >1.6)

Correlation between independently processed samples (from RNA isolation to array readout) from the same biopsy specimen using either all features or only those that were more than 0.3 SDs differentially regulated on all arrays.

Number of features using seven different SDs (ranging from 0.8 to 2.0) and the 80 % filter (sequences needed to be present in at least 80 % of all arrays) or unfiltered data.

Dendrograms similar to figure 2 but with different SDs of >1.0 and >1.6.

Functional roles differentiating CAD from LIV in TI (p<0.1)

Dendrograms similar to figure 2 but with different SDs of >1.0 and >1.6.

Number of putative consensus transcription factor binding sites (matrices) found in the 62 upstream sequences (500 bp) separating TI from G.

Dendrograms similar to figure 2 but with different SDs of >1.0 and >1.6.