Allergen-hybrids - next generation vaccines for Fagales pollen immunotherapy.

Pichler, U., M. Hauser, H. Hofer, M. Himly, E. Hoflehner, M. Steiner, S. Mutschlechner, K. Hufnagl, C. Ebner, A. Mari , P.Briza, B. Bohle, U. Wiedermann, F. Ferreira, M. Wallner.

Dec 11. doi: 10.1111/cea.12250, 2013


Kinetics, cross-reactivity and specificity of Bet v 1-specific IgG4 antibodies induced by immunotherapy with birch pollen

Subbarayal, B., D. Schiller, C. Möbs , N. W. de Jong, C. Ebner, N. Reider, D. Bartel, J. Lidholm, W. Pfützner, R. Gerth van Wijk, S.Vieths and B. Bohle.

Allergy 68(11):1377-86. doi: 10.1111/all.12236, 2013


Recombinant Mal d 1 is a reliable diagnostic tool for birch pollen allergen-associated apple allergy.

Kollmann, D., M. Geroldinger-Simic, T. Kinaciyan, H. Huber, C. Ebner, J. Lidholm and B. Bohle.

J Allergy Clin Immunol,Doi:10.1016/j.jaci.2013.05.030, 2013


Oral exposure to Mal d 1 affects the immune response in birch pollen-allergic patients.

Geroldinger-Simic, M., T. Kinaciyan, B. Nagl, U. Baumgartner-Durchschlag, H. Huber, C. Ebner, J. Lidholm, D. Bartel, S. Vieths, B. Jahn-Schmid and B. Bohle.

J Allergy Clin Immunol, 131:94. doi: 10.1016/j.jaci.2012.06.039, 2013


A hypoallergenic variant of the major birch pollen allergen shows distinct characteristics in antigen processing and T cell activation.

Kitzmüller, C., M. Wallner, S. Deifl, S. Mutschlechner, C. Walterskirchen, G.J. Zlabinger, F. Ferreira and B. Bohle.

Allergy, 67:1375. doi: 10.1111/all.12016, 2012


Association of HLA-DR1 with the allergic response to the major mugwort pollen allergen: molecular background.

Knapp, B., G. Fischer, D. Van Hemelen, I. Fae, B. Maillere, C. Ebner, W. Schreiner, B. Bohle and B. Jahn-Schmid.

BMC Immunol, 13:43, 2012


Human blood basophils do not act as antigen-presenting cells for the major birch pollen allergen Bet v 1.

Kitzmüller, C., B. Nagl, S. Deifl, C. Walterskirchen, B. Jahn-Schmid, G. J. Zlabinger and B. Bohle.

Allergy, 67:593-600. doi: 10.1111/j.1398-9995.2011.02764.x, 2012


Nitration of the Pollen Allergen Bet v 1.0101 Enhances the Presentation of Bet v 1-derived Peptides by HLA-DR on Human Dendritic Cells.

Karle, A.C, G. J. Oostingh, S. Mutschlechner, F. Ferreira, P. Lackner, B. Bohle, G. F. Fischer, A. B. Vogt and A. Duschl.

Plos One, 7:e31483, 2012


Humoral and cellular cross-reactivity between Amb a 1, the major ragweed pollen allergen, and its mugwort homolog Art v 6

Jahn-Schmid, B., M. Hauser, N. Wopfner, P. Briza, U. E. Berger R. Asero, C. Ebner, F. Ferreira, and B. Bohle.

J Immunol, 188:1559, 2012


Human TCR Transgenic Bet v 1-Specific Th1 Cells Suppress the Effector Function of Bet v 1-Specific Th2 Cells

Neunkirchner, A ., V. M. Leb-Reichl, K. G. Schmetterer , S. Mutschlechner, H. J. Kueng, D. Haiderer, K. Schuch, M. Wallner, B. Jahn-Schmid, B. Bohle and W. F. Pickl.

J Immunol, 187:4077,2011


Pru p 3, the non-specific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut

Schulten, V., B. Nagl, E. Scala, M. L. Bernardi, A. Mari, M. A. Ciardiello, I. Lauer, S. Scheurer, P. Briza, A. Jürets, F. Ferreira, B. Jahn-Schmid, G. F. Fischer and B. Bohle.

Allergy, DOI  10.1111/j.1398-9995.2011.02567, 2011


Birch pollen-related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG4 antibodies

Geroldinger-Simic, M., T. Zelniker, W. Aberer, C. Ebner, C. Egger, A. Greiderer, N. Prem, J. Lidholm, B. K. Ballmer- Weber, S. Vieths and B. Bohle.

J Allergy Clin Immunol,  DOI 10.1016/j.jaci.2010.10.027, 2011


Interaction of Allergens, Major Histocompatibility Complex Molecules, and T Cell Receptors: A 'Ménage à Trois' That Opens New Avenues for Therapeutic Intervention in Type I Allergy

Jahn-Schmid, B., W. F. Pickl and B. Bohle.

Int Arch Allergy Immunol, 156(1):27-42, 2011


Reshaping the Bet v 1-fold modulates T-helper polarization

Wallner, M., M. Hauser, M. Himly , N. Zaborsky, S. Mutschlechner, A. Harrer, C. Asam, U. Pichler, R. van Ree, P. Briza, J. Thalhamer, B. Bohle, G. Achatz, and F. Ferreira.

J Allergy Clin Immunol,  Jun;127(6):1571-8.e9, 2011


Protein unfolding strongly modulates the allergenicity and immunogenicity of Pru p 3, the major peach allergen

Toda, M., G. Reese, G. Gadermaier , V. Schulten, I. Lauer, M. Egger, P. Briza , S. Randow, S. Wolfheimer, V. Kigongo, M. Del Mar San Miguel Moncin, K. Fötisch, B. Bohle, S. Vieths and S. Scheurer.

J Allergy Clin Immunol, May 13. [Epub ahead of print] PMID: 21571358 [PubMed - as supplied by publisher], 2011


Bet v 1-specific TCR/Foxp3 transgenic T-cells suppress Bet v 1-specific T- cell effector function in an activation dependent manner

Schmetterer, K., D. Haiderer, V. M. Leb-Reichl, A. Neunkirchner, B. Jahn-Schmid, H.J. Küng, K. Schuch, P. Steinberger, B. Bohle and W. F. Pickl.

J Allergy Clin Immunol.127:238, 2011


Assessing Protein Immunogenicity with a Dendritic Cell Line-Derived Endolysosomal Degradome

Egger, M., A. Jürets, M. Wallner, P. Briza, S. Ruzek, S. Hainzl, U. Pichler, C. Kitzmüller, B. Bohle, C. G. Huber and F. Ferreira.

 PLoS One, Feb 16;6(2):e17278, 2011


Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemodialysis patients

Cejka, D., A. Ja¨ger-Lansky, H. Kieweg, M. Weber, C. Bieglmayer, D. G. Haider, D. Diarra, J. Patsch, F. Kainberger, B. Bohle and M. Haas. 

Nephrol Dial Transplant,  May 25. [Epub ahead of print] PMID: 21613383, 2011


Expression of a Major Plant Allergen as Membrane-Anchored and Secreted Protein in Human Cells with Preserved T Cell and B Cell Epitopes

Baranyi, U., M. Gattringer, A. Boehm, K. Marth, M. Focke-Tejkl, B. Bohle, K. Blatt, P. Valent,  R. Valenta, and T. Wekerle.

Int Arch Allergy Immunol, 156:259-266 (DOI: 10.1159/000323733), 2011


Naturally processed T cell-activating peptides of the major birch pollen allergen

Mutschlechner, S., M. Egger, P. Briza, M. Wallner, P. Lackner, A. Karle, AB. Vogt, GF. Fischer, B. Bohle and F. Ferreira.

J Allergy Clin Immunol., 125(3):711-8, 718.e1-718.e2, 2010


Schmetterer, KG., MG. Seidl, U. Körmöczi, A. Rottal, K. Schwarz, S. Matthes-Martin, P. Steinberger and WF. Pickl

Two newly diagnosed HLA class II deficient patients identified by rapid vector-based complementation reveal dicoordinate invariant chain expression levels

Int Arch Allergy Immunol.,152(4):390-400, 2010


Genetic allergen modification in the development of novel approaches to specific immunotherapy. Clinical and Experimental Allergy

Mutschlechner, S., S. Deifl and B. Bohle

Clin Exp Allergy, 39:1635, 2009


Modulation of allergen-specific T-lymphocyte function by virus-like particles decorated with HLA class II molecules.

Leb, VM., B. Jahn-Schmid, HJ. Kueng, KG. Schmetterer, D. Haiderer, A. Neunkirchner, GF. Fischer, A. Hartl, J. Thalhamer, P. Steinberger, B. Bohle, B. Seed and WF.Pickl

J Allergy Clin Immunol.,124:121, 2009


Characterization of the allergic T-cell response to Pru p 3, the nonspecific lipid transfer protein in peach

Schulten, V., A. Radakovics, C. Hartz, A. Mari, S. Vazquez-Cortes, M. Fernandez-Rivas, I. Lauer, B. Jahn-Schmid, T. Eiwegger, S. Scheurer and B. Bohle

J Allergy Clin Immunol., 124:100, 2009


Natural self-assembly of allergen-S-layer fusion proteins is no prerequisite for reduced allergenicity and T cell stimulatory capacity 
Gerstmayr, M., N. Ilk, B. Jahn-Schmid, U.B. Sleytr and B. Bohle
Int Arch Allergy Immunol., 149:231, 2009
Pubmed Link

3-Layer-based analysis of peptide–MHC interaction: In silico prediction, peptide binding affinity and T cell activation in a relevant allergen-specific model

Knapp, B., U. Omasits, B. Bohle, B. Maillere, C. Ebner, W. Schreiner and B. Jahn-Schmid

Mol Immunol., 46:1839, 2009


Immunologic characterization of isoforms of Car b 1 and Que a 1, the major hornbeam and oak pollen allergens

Wallner, M., A. Erler, M. Hauser, E. Klinglmayr, G. Gadermaier, L. Vogel, A. Mari,B.  Bohle, P. Briza and F. Ferreira

Allergy, 64:452, 2009


Characterization of HLA-class II / peptide-TCR interactions of the immunodominant T cell Epitope in Art v 1, the major mugwort pollen allergen
Jahn-Schmid, B., P. Sirven, V. Leb, W. F. Pickl, G. F. Fischer, G. Gadermaier, M. Egger, C. Ebner F. Ferreira, B. Maillére and B. Bohle
J Immunol., 181:3636, 2008
Pubmed Link

Molecular and functional analysis of the antigen receptor of Art v 1-specific helper T lymphocytes
Leb, V.M., B. Jahn-Schmid, K.G. Schmetterer, H. J. Kueng, D. Haiderer, A. Neunkirchner, G. F. Fischer, K. Nissler, A. Hartl, J. Thalhamer, B. Bohle, B. Seed, W. F. Pickl
J Allergy Clin Immunol., 121:64, 2008 
 Pubmed Link