Aspartyl proteases (also named acid protease) contain two conserved aspartate residues in their catalytic centers . This family includes pepsins, cathepsins, and renins.
Allergens belonging to this family include the major cockroach allergen Bla g 2  and several fungal allergens. In addition, the γ-conglutin seed storage proteins from lupine seeds belong to this family .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00026||Eukaryotic aspartyl protease||CL0129||Peptidase clan AA|
|PF14541||Xylanase inhibitor C-terminal||CL0129||Peptidase clan AA|
|PF14543||Xylanase inhibitor N-terminal||CL0129||Peptidase clan AA|
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