The cystatin superfamily of reversibly binding cysteine protease inhibitors has been divided into three animal families, stefins, cystatins and kinenogens, and one plant cystatin family, phytocystatins . Most phytocystatins are 12-14 kDa in size, contain no disulfide bonds, and show significant amino acid sequence similarity to the cystatin families of animal origin .
Allergens belonging to the phytocystatins are found in kiwifruit (Actinidia deliciosa), gold kiwifruit (Actinidia chinensis) , and short ragweed (Ambrosia artemisiifolia) . Among animal cystatins, Fel d 3 from cat and Ani s 4 from Anisakis simplex were identified as allergens [5, 6].
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00031||Cystatin domain||CL0121||Cystatin-like superfamily|
|PF16845||Aspartic acid proteinase inhibitor||CL0121||Cystatin-like superfamily|
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