Intermediate filaments (IF) are proteins which are primordial components of the cytoskeleton and the nuclear envelope. IF proteins are members of a very large multigene family which has been subdivided into five major subgroups. While IF proteins are evolutionary and structurally related, they have limited sequence similarities .
Human cytokeratin 6A (Hom s 5) was described to be an autoallergen for atopic dermatitis patients .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00038||Intermediate filament protein||-|
|PF16208||Keratin type II head||-|
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