The subtilisin family is the second largest serine protease family characterized to date . Its members are found in archaea, bacteria, eukaryotes, and viruses. Structures have been determined for several members of the subtilisin family. They contain the same catalytic triad as the chymotrypsins, although the residues occur in a different order. Apart from this, the structures show no other similarities.
Most allergens from this family are fungal allergens. They belong to the subfamilies of alkaline (Asp f 13 from Aspergillus fumigatus and Pen c 1 from Penicillium citrinum) or vacuolar serine proteases (Asp f 18 and Pen c 18) . The only plant allergens known to belong to this family is Cuc m 1 from muskmelon .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF05922||Peptidase inhibitor I9||CL0570||Protease propeptides/inhibitors|
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