Thioredoxins are small enzymes that participate in redox reactions via the reversible oxidation of an active center disulfide bond . They serve as general protein disulfide oxidoreductases and interact with a broad range of proteins. Protein disulfide isomerases contain two active redox domains similar to thioredoxins. Redoxins (AllFam:AF131) are redox enzymes closely-related to thioredoxin.
Allergenic thioredoxins are found in fungi as well as in plants. The fungal allergens Asp f 28 and Asp f 29 from Aspergillus fumigatus and Mala s 13 from Malassezia sympodialis are thioredoxins, while Alt a 4 from Alternaria alternata is a protein disulfide isomerase . Allergenic thioredoxins from plants include cereal allergens associated with baker's asthma .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
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