This group of serine proteases belongs to the MEROPS peptidase families S1 (chymotrypsin family, clan PA(S)). The chymotrypsin family is almost totally confined to animals. The enzymes are either secreted directly or packaged into vesicles for regulated secretion .
Allergens from the trypsin family constitute three groups of mite and cockroach allergens . Group 3 mite allergens are trypsins and are major constituents of mite faeces. Trypsins are also found in cockroaches . Group 6 mite allergens are chymotrypsins and show no cross-reactivity with group 3 allergens. Group 9 allergens exhibit a collagenase activity. Trypsin-like allergens are also found in insect venoms . The dog allergen Can f 5 is an arginine esterase that belongs to this family.
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00089||Trypsin||CL0124||Peptidase clan PA|
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