AF029: Zn-containing dehydrogenase

List allergens from this family:

Sources:
Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Zinc-containing alcohol dehydrogenases are found in bacteria, mammals, plants, and in fungi. They are dimeric or tetrameric enzymes that bind two atoms of zinc per subunit [1]. A number of other zinc-dependent dehydrogenases are closely related to zinc ADH such as sorbitol dehydrogenase, L-threonine 3-dehydrogenase, glutathione-dependent formaldehyde dehydrogenase, mannitol dehydrogenase, and NADP-dependent quinone oxidoreductase.

Allergens from this family

The allergen Cand a 1 from Candida albicans is an alcohol dehydrogenase [2].

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References

  1. Sun HW, Plapp BV:
    Progressive sequence alignment and molecular evolution of the Zn-containing alcohol dehydrogenase family.
    J Mol Evol 1992, 34, 522-35. [PubMed]
  2. Shen HD, Choo KB, Lee HH, Hsieh JC, Lin WL, Lee WR, Han SH:
    The 40-kilodalton allergen of Candida albicans is an alcohol dehydrogenase: molecular cloning and immunological analysis using monoclonal antibodies.
    Clin Exp Allergy 1991, 21, 675-81. [PubMed]

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Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00107 Zinc-binding dehydrogenase CL0063 FAD/NAD(P)-binding Rossmann fold Superfamily
PF08240 Alcohol dehydrogenase GroES-like domain CL0296 GroES-like superfamily

Links to Wikipedia

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