Zinc-containing alcohol dehydrogenases are found in bacteria, mammals, plants, and in fungi. They are dimeric or tetrameric enzymes that bind two atoms of zinc per subunit . A number of other zinc-dependent dehydrogenases are closely related to zinc ADH such as sorbitol dehydrogenase, L-threonine 3-dehydrogenase, glutathione-dependent formaldehyde dehydrogenase, mannitol dehydrogenase, and NADP-dependent quinone oxidoreductase.
The allergen Cand a 1 from Candida albicans is an alcohol dehydrogenase .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00107||Zinc-binding dehydrogenase||CL0063||FAD/NAD(P)-binding Rossmann fold Superfamily|
|PF08240||Alcohol dehydrogenase GroES-like domain||CL0296||GroES-like superfamily|
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