Glycoside hydrolase family 17 comprises enzymes from plants and fungi with several known activities: endo-1,3-β-glucosidase, lichenase, and exo-1,3-glucanase. They fold into an (αβ)8 TIM barrel structure. Some glucanases contain on their C-terminus an X8 domain (Pfam:PF07983), a small domain that contains 6 conserved cysteine residues that presumably form three disulphide bridges . Two X8-family members from Arabidopsis thaliana were identified as callose-binding plasmodesma proteins that provide an anchor between the plasma membrane and the cell wall .
β-1,3-Glucanases from plants were described as allergens in Hevea brasiliensis latex , olive pollen  and plant foods . They are glycoproteins that contain IgE-binding N-linked glycans and are thought to be involved in the latex-fruit syndrome. Olive pollen glucanase, Ole e 9, contains an X8 domain at its C-terminus. Ole e 10 consists only of an X8-domain, lacking a glucanase domain .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00332||Glycosyl hydrolases family 17||CL0058||Tim barrel glycosyl hydrolase superfamily|
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