Transferrins are eukaryotic iron-binding glycoproteins that control the level of free iron in biological fluids. The proteins evolved by duplication of a domain, each duplicated domain binding one iron atom. Members of the family include blood serotransferrin (siderophilin), milk lactotransferrin (lactoferrin), egg white ovotransferrin (conalbumin), and membrane-associated melanotransferrin .
Allergens from this family
Bovine lactoferrin was identified as an allergen binding IgE from 50% of cow's milk allergic patients' sera . Chicken ovotransferrin (Gal d 3) is a major hen's egg allergen .
Evolution of the transferrin family: conservation of residues associated with iron and anion binding.
Comp Biochem Physiol B Biochem Mol Biol 2005, 142, 129-41. [PubMed] [Full Text]
Cow's milk allergens identification by two-dimensional immunoblotting and mass spectrometry.
Mol Nutr Food Res 2004, 48, 363-9. [PubMed] [Full Text]
Identification of IgE-binding egg white proteins: comparison of results obtained by different methods.
Int Arch Allergy Immunol 1996, 109, 50-7. [PubMed]
Links to Pfam
Family-defining Pfam domains (at least one of these domains is present in each family member):
Periplasmic binding protein clan
Links to Wikipedia
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