The 60S acidic ribosomal proteins are part of the large ribosome subunit and play an important role in the elongation step of protein synthesis. This family includes archaeal L12, and eukaryotic P0, P1 and P2 .
Members of this family were described as fungal allergens. Alt a 12 from Alternaria alternata and Cla h 12 from Cladosporium herbarum are P1 proteins, while Alt a 5, Cla h 5 and Asp f 8 from Aspergillus fumigatus belong to the P2 family . Autoimmune reactions to human P2 were also described .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00428||60s Acidic ribosomal protein||-|
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