Staphylococcus aureus is a Gram-positive coccus that is the major cause of nosocomial infections due to its multiple antibiotic resistant nature. One of the major virulence exotoxins is toxic shock syndrome toxin (TSST), which is secreted by the organism upon successful invasion. It causes a major inflammatory response in the host via superantigenic properties, and is the causative agent of toxic shock syndrome [1]. Other members of this family are staphylococcal enterotoxins and streptococcal pyrogenic exotoxins.
Staphylococcal enterotoxins were described as IgE-binding protein involved in the exacerbation of atopic dermatitis [2].
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF01123 | Staphylococcal/Streptococcal toxin, OB-fold domain | - | |
| PF02876 | Staphylococcal/Streptococcal toxin, beta-grasp domain | CL0386 | Superantigen toxins, C-terminal domain superfamily |
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