Hyaluronidases (glycoside hydrolase family 56) are enzymes that degrade hyaluronic acid. They are found exclusively in animals. The human genome contains six genes from this family including PH-20, a membrane protein of mammalian sperm involved in sperm-egg adhesion . Moreover, Hyaluronidases are components of venoms from various groups of animals .
Hyaluronidases are the group 2 allergens of bee and vespid venoms. They are glycoproteins that contain IgE binding N-glycans .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF01630||Hyaluronidase||CL0058||Tim barrel glycosyl hydrolase superfamily|
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