This family contains different NADP-dependent oxidoreductases involved in plant secondary metabolism, as there are isoflavone reductases, phenylcoumaran benzylic ether reductases, and pinoresinol-lariciresinol reductases . Another family member is NmrA, a negative transcriptional regulator involved in the post-translational modification of the transcription factor AreA. NmrA is part of a system controlling nitrogen metabolite repression in fungi .
Allergens from this family include the minor birch pollen allergen Bet v 6, which was shown to cross-react with homologous proteins from plant food , and an allergen from Japanese cedar pollen .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF05368||NmrA-like family||CL0063||FAD/NAD(P)-binding Rossmann fold Superfamily|
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