Uteroglobin (or blastokinin) is a mammalian steroid-inducible secreted protein originally isolated from the uterus of rabbits during early pregnancy. The mucosal epithelia of several organs that communicate with the external environment express uteroglobin. Uteroglobin may be a multi-functional protein with anti-inflammatory/immunomodulatory properties, inhibiting phospholipase A2 activity, and binding to (and possibly sequestering) several hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids and prostaglandins. Ulteroglobin is a member of the secretoglobin family that also contains mammaglobin, lipophilin B, and the cat allergen Fel d 1 . Members of this family form disulfide-linked homo- or heterodimers. The subunits adopt a helical fold composed of 4 helices.
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF01099||Uteroglobin family||CL0370||Uteroglobin-like superfamily|
|PF09252||Allergen Fel d I-B chain||CL0370||Uteroglobin-like superfamily|
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