These serine protease inhibitors inhibit proteases from the chymotrysin (S1) and subtilisin (S8) families. These inhibitors are small (60 to 90 residues) and, in contrast with other families of protease inhibitors, they lack disulfide bonds. Members of this family are found in potatoes and wide range of other plant species. This family is classified among the plant pathogenesis-related proteins as family PR-6 [1].
A protease inhibitor from wheat was identified as a minor wheat allergen for patients with baker's asthma, but not for patients with wheat-induced food allergy [2].
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF00280 | Potato inhibitor I family | CL0367 | CI-2 family of serine protease inhibitors |
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