Methionine synthases or 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases from bacteria and plants catalyse the last step in the production of methionine by transferring a methyl group from 5-methyltetrahydrofolate to homocysteine. In animals, this enzyme requires Vitamin B12 (cobalamin) as a cofactor, whereas the form found in plants is cobalamin-independent. Microorganisms express both cobalamin-dependent and cobalamin-independent forms .
The pollen allergen Sal k 3 from Russian thistle (Salsola kali) belongs to this family. The recombinant protein bound IgE from two thirds of the tested patients .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF01717||Cobalamin-independent synthase, Catalytic domain||CL0160||Cobalamin-independent synthase|
|PF08267||Cobalamin-independent synthase, N-terminal domain||CL0160||Cobalamin-independent synthase|
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