Tick histamine binding proteins are secreted into the tick saliva and sequester histamine at the wound site. Because the tick histamine binding proteins outcompete histamine receptors, they are able to overcome host inflammatory responses. These proteins are structurally related to lipocalins (AllFam:AF015) without any significant sequence similarity .
The European pigeon tick (Argas reflexus) is a parasite of wild pigeons colonizing urban buildings and houses. Occasionally the ticks can bite humans, inducing anaphylactic reactions in sensitized patients. The major allergen, Arg r 1, belongs to the histamine binding protein family .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF02098||Tick histamine binding protein||CL0116||Calycin superfamily|
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