Members of this family act as chaperones that can protect other proteins against heat-induced denaturation and aggregation . Hsp20 proteins seem to form large hetero-oligomeric aggregates. HSP20 proteins are evolutionarily related to α-crystallin, an abundant constituent of the eye lens of most vertebrate species .
Cas s 9 from chestnut is a Hsp20 that was found to bind IgE from nearly half of the tested chestnut-allergic patients.
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00011||Hsp20/alpha crystallin family||CL0190||HSP20-like chaperone superfamily|
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