The RNA recognition motif (RRM, RBD, or RNP domain) is found in a variety of RNA-binding proteins, including heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu). The typical RRM consists of four anti-parallel beta-strands and two alpha-helices arranged in a beta-alpha-beta-beta-alpha-beta fold with side chains that stack with RNA bases .
The fungal allergen Cop c 3 from shaggy mane (Coprinus comatus) belongs to this family.
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00076||RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)||CL0221||RRM-like clan|
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