Members of this family are found exclusively in fungi. Their function is unknown. The structure of Alt a 1 from Alternaria alternata was determined. The allergen folds into a unique 11-stranded β-barrel and forms dimers connected by a single disulfide bond .
Alt a 1 is a major allergen binding IgE from more than 90% of patients allergic to Alternaria .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF16541||Alternaria alternata allergen 1||-|
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