Fructose-bisphosphate aldolase, often just aldolase, is an enzyme catalyzing a reversible reaction that splits the aldol, fructose 1,6-bisphosphate, into the triose phosphates dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Aldolase can also produce DHAP from other (3S,4R)-ketose 1-phosphates such as fructose 1-phosphate and sedoheptulose 1,7-bisphosphate. Gluconeogenesis and the Calvin cycle use the reverse reaction. Aldolases are divided into two classes by mechanism [1]. Members of both families fold into a TIM barrel but show little sequence similarity. With few exceptions, only class I proteins have been found in animals, plants, and green algae while only class II proteins have been found in fungi. Both classes have been found widely in other eukaryotes and in bacteria.
Aldolases were identified as major fish allergens with limited cross-reactivity [2].
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF00274 | Fructose-bisphosphate aldolase class-I | CL0035 | Peptidase clan MH/MC/MF |
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