Nematode polyprotein allergens are lipid-binding proteins specific to nematodes. They are synthesized as large, tandemly repetitive polyproteins that are post-translationally cleaved into multiple copies of small lipid binding proteins with virtually identical fatty acid and retinol-binding characteristics. They are probably central to transport and distribution of small hydrophobic compounds between the tissues, and may play key roles in nutrient scavenging and immunomodulation. The proteins adopt a novel seven-helical fold comprising a long central helix that participates in two hollow four-helical bundles on either side .
ABA-1 proteins are important IgE-binding antigens of parasitic nematodes .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF16469||Nematode polyprotein allergen ABA-1||-|
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