AF213: RidA/YjgF/L-PSP family
This family contains trimeric proteins with high functional diversity found in all three domains of life [1
]. RidA proteins (also named YjgF) have imine/enamine deaminase activity and function in removing toxic metabolic by-products [2
]. Rat liver perchloric acid soluble protein (L-PSP) is an endoribunuclease that cleaves single-stranded DNA. L-PSP was shown to inhibit translation by cleaving mRNA [3
Allergens from this family
The house dust mite allergen Der f 34 is the only known allergenic member of this family [4
]. Der f 34 was shown to have imine deaminase activity and bound IgE from more than 60% of mite allergic patients. Furthermore, IgE cross-reactivity with the mold Aspergillus fumigatus
Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family.
BMC Genomics 2015, 16, 382. [PubMed] [Full Text]
RidA proteins prevent metabolic damage inflicted by PLP-dependent dehydratases in all domains of life.
MBio 2013, 4, e00033-13. [PubMed] [Full Text]
Ribonuclease activity of rat liver perchloric acid-soluble protein, a potent inhibitor of protein synthesis.
J Biol Chem 1999, 274, 20688-92. [PubMed]
Der f 34, a Novel Major House Dust Mite Allergen Belonging to a Highly Conserved Rid/YjgF/YER057c/UK114 Family of Imine Deaminases.
J Biol Chem 2016, (in press)[PubMed] [Full Text]
Links to Pfam
Family-defining Pfam domains (at least one of these domains is present in each family member):
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