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recent
publications
2010
Sakaguchi S, Hombauer M, Bilic I, Naoe Y, Schebesta A, Taniuchi I, Ellmeier W. (2010) The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes.
Nat Immunol. 11(5):442-8. PubMed link
Grausenburger, R, Bilic, I., Boucheron, N., Zupkovitz, G., El-Housseiny, L., Tschismarov, R., Zhang, Y., Rembold, M., Gaisberger, M., Hartl, A., Epstein, M.M., Matthias, P., Seiser, C., Ellmeier, W. (2010). Conditional deletion of HDAC1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. Journal of Immunology, in press.
2009
Köprülü, A.D. and Ellmeier, W. (2009). The Role of Tec Family Kinases in Mononuclear Phagocytes. Critical Reviews in Immunology, 29(4):317-33. PubMed link
Schmidt, U., Abramova, A., Boucheron, N., Eckelhart, E., Schebesta, A., Bilic, I., Kneidinger, M., Unger, B., Hammer, M., Sibilia, M, Valent, P. and Ellmeier, W. (2009). The protein tyrosine kinase Tec regulates mast cell function. European Journal of Immunology, 39(11): 3228-28. PubMed link
Blomberg KE, Boucheron N, Lindvall JM, Yu L, Raberger J, Berglöf A, Ellmeier W, Smith CE. Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells. (2009). BMC Genomics, 10, 233. PubMed link
2008
Raberger, J., Schebesta, A., Sakaguchi, S., Boucheron, N., Blomber, K.M., Berglöf, A., Kolbe, T., Smith, C.I.E., Rülicke, T., and Ellmeier, W. (2008). The Transcriptional Regulator PLZF Induces the Development of CD44-High Memory-Phenotype T Cells. PNAS, 105, 17919-24. PubMed link
Raberger, J., Boucheron , N. , Sakaguchi, S., Penninger, J.M. and Ellmeier , W. (2008). Impaired T cell development in the absence of Vav1 and Itk. European Journal of Immunology, 38, 3530-42. PubMed link
Melcher, M., Unger, B., Schmidt, U., Rajantie, I.A., Alitalo, K., and Ellmeier, W. (2008). Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. 2008. The Journal of Immunology, 180, 8048-56. PubMed link
Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H. (2008). Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell, 132, 794-806. PubMed link
Kneidinger M, Schmidt U, Rix U, Gleixner KV, Vales A, Baumgartner C, Lupinek C, Weghofer M, Bennett KL, Herrmann H, Schebesta A, Thomas WR, Vrtala S, Valenta R, Lee FY, Ellmeier W, Superti-Furga G, Valent P. (2008). The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood, 111, 3097-107. PubMed link
2007
Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A. (2007). 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nature Immunology, 8, 1049-59. PubMed link
Hantschel O, Rix U, Schmidt U, Burckstummer T, Kneidinger M, Schutze G, Colinge J, Bennett KL, Ellmeier W, Valent P, Superti-Furga G. (2007). The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. PNAS. 104, 13283-8. PubMed link
Bilic, I., and Ellmeier, W. (2007). The role of BTB domain-containing zinc finger proteins in T cell development and function. Immunol Lett. 108, 1-9. PubMed link
Taschner, S., Koesters, C., Platzer, B., Jorgl, A., Ellmeier, W., Benesch, T., Strobl, H. Downregulation of RXR{alpha} expression is essential for neutrophil development from granulocyte/monocyte progenitors. (2007). Blood, 109, 971-9. PubMed link
Koesters, C., Unger, B. Bilic, I., Bluml, S., Lichtenberger, B., Schreiber, M., Stockl, J. and Ellmeier, W. (2007). Regulation of dendritic cell differentiation, maturation and subset distribution by the zinc finger protein CTCF. Immunology Letters, 109, 165-74. PubMed link
2006
Bilic, I., Koesters, C., Unger, B., Sekimata, M., Hertweck, A., Maschek, R., Wilson, C.B. and Ellmeier, W. (2006).
Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nature Immunology, 7, 393-400. PubMed link
2005
Sarafova, S.D., Erman, B., Yu, O., Van Laethem, F., Guinter, T., Sharrow, S.O., Feigenbaum, L., Wildt, F.L., Ellmeier, W. and Singer, A. (2005). Transcriptional Modulation of Coreceptor Expression during Positive Selection Dictates Lineage Fate Independently of TCR Specificity and Coreceptor Protein Identity, Immunity, 23:75-87. PubMed link
Marquez, M.E., Ellmeier, W ., Sanchez-Guajardo, V., Freitas, A.A., Acuto, O. and Di Bartolo, V. (2005) CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens. The Journal of Immunology, J Immunol., 175(11):3788-97. PubMed link
Feik,
N., Bilic, I., Tinhofer, J., Unger, B., Littman, D.R. and Ellmeier,
W. (2005). Functional and Molecular Analysis of the Double-Positive
Stage-specific CD8 Enhancer E8III During Thymocyte Development.
J Immunol., 174(3):1513-24. PubMed link
2004
Yu
PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae
K, Ellmeier W, Witte ON, Rawlings, D.R. (2004). Sustained correction
of B cell development and function in a murine model of X-linked
agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
Blood,
104(5):1281-90. PubMed link
Madakamutil
LT, Christen U, Lena CJ, Wang-Zhu Y, Attinger A, Sundarrajan M,
Ellmeier W, von Herrath MG, Jensen P, Littman DR, Cheroutre H. (2004).
CD8alphaalpha mediated survival and differentiation of CD8 memory
T cell precursors. Science, 304, 590-93. PubMed link
Taniuchi,
I., Ellmeier, W., Littman, D.R. (2004). The CD4/CD8 Lineage Choice:
New Insights into Epigenetic Regulation During T Cell Development.
Adv. Immunology. Vol 83, 55-89. PubMed link
Schmidt,
U., Boucheron, N., Unger, B., Ellmeier, W. (2004). The role of Tec
family kinases in myeloid cells. Int Arch of Allergy Immunol., 134,
65-78. PubMed link
Schmidt,
U., Van Den Akker, E., Parren-Van Amelsvoort ,M., Litos, G., De
Bruijn , M., Gutierrez, L., Hendriks, R.W., Ellmeier, W., Lowenberg,
B., Beug, H,. Von Lindern, M. (2004). Btk Is Required for an Efficient
Response to Erythropoietin and for SCF-controlled Protection against
TRAIL in Erythroid Progenitors. J Exp Med, 199, 785-795. PubMed link
2003
Atkinson,
B.T., Ellmeier, W., Watson, S.P. (2003). Tec regulates platelet activation
by GPVI in the absence of Btk. Blood, 102, 3592-9. PubMed link
2002
Kioussis,
D., Ellmeier, W. (2002). Chromatin and CD4, CD8A and CD8B gene expression
during thymic differentiation. Nat Rev Immunol, 2, 909-19. PubMed link
Ellmeier,
W., Sunshine, M.J., Maschek, R., Littman, D.R. (2002). Combined
deletion of CD8 locus cis-regulatory elements affects initiation
but not maintenance of CD8 expression. Immunity, 16, 623-34. PubMed link
Keppler,
O.T., Welte, F.J., Ngo, T.A., Chin, P.S., Patton, K.S., Tsou, C.L.,
Abbey, N.W., Sharkey, M.E., Grant, R.M., You, Y., Scarborough, J.D.,
Ellmeier, W., Littman, D.R., Stevenson, M., Charo, I.F., Herndier,
B.G., Speck, R.F., Goldsmith, M.A. (2002). Progress toward a human
CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency
virus type 1. Journal of Experimental Medicine, 195, 719-36. PunMed link
2001
Donnadieu,
E., Lang, V., Bismuth, G., Ellmeier, W., Acuto, O., Michel, F.,
Trautmann, A. (2001). Differential roles of Lck and Itk in T cell
response to antigen recognition revealed by calcium imaging and
electron microscopy. Journal of Immunology, 166, 5540-9. PubMed link
2000
Ellmeier, W., Jung, S., Sunshine, M.J., Hatam, F.,
Xu, Y, Baltimore, D., Mano, H. and Littman, D.R. (2000). Severe
B Cell Deficiency in Mice Lacking the Tec Kinase Family Members
Tec and Btk. The Journal of Experimental Medicine, 192, 1611-24. PubMed link
Sun,
Z., Arendt, C.W., Ellmeier, W., Schaeffer, E.M., Sunshine, M.J.,
Gandhi, L., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg,
P.L., Littman, D.R. (2000). PKC-theta is required for TCR-induced
NF-kappaB activation in mature but not immature T lymphocytes. Nature,
404, 402-7. PubMed link
1996-1999
Ellmeier, W., Sawada, S. and Littman, D.R. (1999). The Regulation
of CD4 and CD8 Coreceptor Gene Expression During T Cell Development.
Annual Reviews of Immunology, 17, 523-554. PubMed link
Ellmeier, W., Sunshine, M.J., Losos, K. and Littman, D.R.
(1998). Multiple Developmental Stage-Specific Enhancers Regulate
CD8 Expression In Developing Thymocytes and in Thymus-Independent
T Cells. Immunity, 9, 485-496. PubMed link
Ellmeier, W., Sunshine, M.J., Losos, K., Hatam, F.
and Littman, D.R. (1997). An Enhancer that Directs Lineage-Specific
Expression of CD8 in Positively Selected Thymocytes and Mature T
cells. Immunity, 7, 537-547. PubMed link
Deng,
H., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M.,
Di Marzio, P., Marmon, S., Sutton, R.E., Hill, C.M., Davis, C.B.,
Peiper, S.C., Schall, T.J., Littman, D.R., Landau, N.R. (1996).
Protein Identification of a major co-receptor for primary isolates
of HIV-1. Nature, 381, 661-6. PubMed link
1991-1996
Ellmeier, W., Barnas, C., Kobrna, A., Kleiner, E., Kurzbauer, R. and Weith, A. (1996). Cloning and Characterization of CpG islands of the Human Chromosome 1p36 Region. Genomics, 32, 155-158. PubMed link
Ellmeier, W. and Weith, A. (1995). Expression of Id3 during murine embryonic development. Developmental Dynamics, 203, 163-173. PubMed link Barnas, C., Kleiner, E., Ellmeier, W., Henn, T., Brunner, C., Stapelton, P. and Weith, A. (1995). Megabasepair-sized grouped sets of microclones: a first generation physical map of chromosome 1pter - p35. Genomics, 29, 607-615. PubMed link
Aguzzi, A., Ellmeier, W. and Weith, A. (1992). Dominant and recessive molecular changes in neuroblastomas. Brain Pathology, 2, 195-208. PubMed link
Ellmeier, W., Aguzzi, A., Kleiner, E., Kurzbauer, R. and Weith, A. (1992). Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. EMBO J., 11, 2563-2571. PubMed link Eckner, R., Ellmeier, W. and Birnstiel, M.L. (1991). Mature mRNA 3' end formation stimulates RNA export from the nucleus. EMBO J., 10, 3513-3522. PubMed link
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