We have so far published 90 scientific papers (including reviews and editorials) with a cumulative impact factor of > 915 (IF value 2019/20) (10.4 IF/publication). Our papers have been cited >7000x (excluding self-citations) (Web of Science).
Andersen L, Gülich AF, Alteneder M, Preglej T, Orola MJ, Dhele N, Stolz V, Schebesta A, Hamminger P, Hladik A, Floess S, Krausgruber T, Faux T, Andrabi SBA, Huehn J, Knapp S, Sparwasser T, Bock C, Laiho A, Elo LL, Rasool O, Lahesmaa R, Sakaguchi S, Ellmeier W. (2019). The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells. Cell Rep. 29(13):4447-4459.e6. doi: 10.1016/j.celrep.2019.11.089 PubMed link
FOXP3+ Treg cells are essential for maintaining tolerance and immune homeostasis. Here we reveal that MAZR is an important factor in regulating the delicate balance of Treg cell generation and report that MAZR expression levels play a key role in controlling Treg cell development and differentiation.
Ellmeier W and Seiser C. (2018). Histone deacetylase function in CD4+ T cells. Nature Reviews Immunology, 18, 617-634. PubMed link
Histone deacetylases (HDACs) and histone acetyltransferases mediate reversible acetylation of histones and many other non-histone proteins to regulate gene expression and protein function. Here, we describe the myriad activities of HDACs in CD4+ T cells and the potential use of HDAC inhibitors as therapeutics for immune-mediated diseases.
Göschl L, Preglej T, Hamminger P, Bonelli M, Andersen L, Boucheron N, Gülich AF, Müller L, Saferding V, Mufazalov IA, Hirahara K, Seiser C, Matthias P, Penz T, Schuster M, Bock C, Waisman A, Steiner G, Ellmeier W. (2017). A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. Journal of Autoimmunity, pii: S0896-8411(17)30595-4. doi: 10.1016/j.jaut.2017.09.008. PubMed link
Here were report that HDAC1 function in T cells is important for the development of experimental autoimmune encephalomyelitis. These data suggest that selective inhibition of HDAC1 might be a novel treatment strategy for multiple sclerosis.
Sakaguchi, S., D. Hainberger, C. Tizian, H. Tanaka, T. Okuda, I. Taniuchi, and W. Ellmeier. 2015. MAZR and Runx Factors Synergistically Repress ThPOK during CD8+ T Cell Lineage Development. J Immunol. 195(6):2879-87. PubMed link
Here we demonstrate developmental stage-specific synergistic activities between MAZR and Runx/CBFβ complexes. Further, we show that MAZR is part of the molecular machinery that maintains a repressed state of ThPOK in CD8+ T cells.
Boucheron, N, Tschismarov, R, Goeschl, L, Moser, Mirjam, Lagger, S, Sakaguchi, S, Winter, Lenz, F, Vitko, D., Breitwieser, FP, Haust, L, Hassan, H, Bennett, KL, Colinge, J, Schreiner, W, Matthias, P, Egawa, T, Taniuchi, I, Matthias, P, Seiser, C* and Ellmeier, W.* (2014). CD4 T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nature Immunology, 15(5):439-48. (*shared senior-authorship). PubMed link
Here we revealed am unexpected plasticity of CD4+ T cells towards the cytotoxic lineage. We demonstrate that HDAC1 and HDAC2 are essential to maintain the integrity of CD4+ T cells by repressing repressing Runx-CBFβ complexes that otherwise induce a CD8+ effector T cell-like program in CD4+ T cells.
Hassan, H., Sakaguchi, S., Tenno, M., Kopf, A., Boucheron, N. Carpenter, A., Egawa, T., Taniuchi, I. Ellmeier, W. (2011) Cd8 enhancer E8I and Runx factors regulate CD8α expression in activated CD8+ T cells. PNAS, 108(45):18330-5. PubMed link
Our data suggest an E8I- and Runx3/CBFβ-dependent epigenetic programming of the Cd8a locus during T-cell activation, leading to Runx/CBFβ complex-independent maintenance of CD8α expression in effector T cells.
Sakaguchi S, Hombauer M, Bilic I, Naoe Y, Schebesta A, Taniuchi I, Ellmeier, W. (2010). The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nature Immunology, 11:442-8 (selected in News & Views section). PubMed link
Here we identified that MAZR regulates CD8 lineage differentiation by repressing ThPOK in MHC class I-signaled DP thymocytes.
Grausenburger, R, Bilic, I., Boucheron, N., Zupkovitz, G., El-Housseiny, L., Tschismarov, R., Zhang, Y., Rembold, M., Gaisberger, M., Hartl, A., Epstein, M.M., Matthias, P., Seiser, C.*, Ellmeier, W.* (2010). Conditional deletion of HDAC1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. Journal of Immunology, 185(6): 3489-97 (selected for “in this issue” section). (*shared senior-authorship). PubMed link
In this manuscript we show that HDAC1 attenuates cytokine production in effector Th2 cells and, thereby, controls airway inflammation.
Raberger, J., Schebesta, A., Sakaguchi, S. Boucheron, N., Blomberg, E.M., Bergloef, A., Kolbe, T., Smith, C.I.E., Rülicke, T, and Ellmeier, W. (2008). The Transcriptional Regulator PLZF Induces the Development of CD44-High Memory-Phenotype T Cells. PNAS, 105.17919. PubMed link
This is one of the first studies showing that PLZF is a novel transcriptional regulator for the development of CD44hi T cells with innate-like features.
Bilic, I., Kösters, K., Unger, B., Sekimata, M. Hertweck, A., Maschek, R., Wilson, C.B. and Ellmeier, W. (2006). Negative regulation of CD8 expression via CD8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nature Immunology, 7, 392-400. PubMed link
In this study we demonstrate epigenetic control of the Cd8 locus and identified that the transcription factor MAZR is an important regulator of CD8 expression.
Feik, N., Bilic, I., Tinhofer, J., Unger, B., Littman, D.R. and Ellmeier, W. (2005). Functional and Molecular Analysis of the Double-Positive Stage-specific CD8 Enhancer E8III During Thymocyte Development. The Journal of Immunology, 174, 1513-2. PubMed link
In this study we demonstrate that E8III is one of the cis-elements that contribute to the activation of the Cd8a and Cd8b gene complex during T cell development.
Ellmeier,
W.,* Sunshine, M.J., Maschek, R., Littman, D.R. (2002). Combined
deletion of CD8 locus cis-regulatory elements affects initiation
but not maintenance of CD8 expression. Immunity, 16, 623-34.*corresponding author. PubMed link
Here we show that the initiation of CD8 expression is mediated by cis-regulatory elements that are distinct from any that may be involved in maintenance of expression. Further, we show that an active state of CD8 gene expression is epigenetically maintained during development of DP thymocytes.
2022
90. Preglej T and Ellmeier W., (2022). CD4 + Cytotoxic T cells - Phenotype, Function and Transcriptional Networks Controlling Their Differentiation Pathways. Immunol Lett. 2022 Jul;247:27-42. doi: 10.1016/j.imlet.2022.05.001. PubMed link
2021
89. Sandner L, Alteneder M, Zhu C, Hladik A, Högler S, Rica R, Van Greuningen LW, Sharif O, Sakaguchi S, Knapp S, Kenner L, Trauner M, Ellmeier W, Boucheron N. (2021). The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven Intestinal Inflammation. Front Immunol. 12:750466. doi: 10.3389/fimmu.2021.750466. PubMed link
88. Zhu C, Boucheron N, Müller AC, Májek P, Claudel T, Halilbasic E, Baazim H, Lercher A, Viczenczova C, Hainberger D, Preglej T, Sandner L, Alteneder M, Gülich AF, Khan M, Hamminger P, Remetic J, Ohradanova-Repic A, Schatzlmaier P, Donner C, Fuchs CD, Stojakovic T, Scharnagl H, Sakaguchi S, Weichhart T, Bergthaler A, Stockinger H, Ellmeier W, Trauner M. (2021). 4-NorUrsodeoxycholic acid reshapes immunometabolism in CD8 + T-cells and alleviates hepatic inflammation. 75(5):1164-1176. doi: 10.1016/j.jhep.2021.06.036. PubMed link
87. Hamminger P, Marchetti L, Preglej T, Platzer R, Zhu C, Kamnev A, Rica R, Stolz V, Sandner L, Alteneder M, Kaba E, Waltenberger D, Huppa JB, Trauner M, Bock C, Lyck R, Bauer J, Dupré L, Seiser C, Boucheron N, Engelhardt B, Ellmeier W. (2021). Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases. J Autoimmun. 119:102610. doi: 10.1016/j.jaut.2021.102610. PubMed link
86. Mayer KA, Smole U, Zhu C, Derdak S, Minervina AA, Salnikova M, Witzeneder N, Christamentl A, Boucheron N, Waidhofer-Söllner P, Trauner M, Hoermann G, Schmetterer KG, Mamedov IZ, Bilban M, Ellmeier W, Pickl WF, Gualdoni GA, Zlabinger GJ. (2021). The energy sensor AMPK orchestrates metabolic and translational adaptation in expanding T helper cells. FASEB J. 35(4):e21217. doi: 10.1096/fj.202001763RR. PubMed link
85. Gülich AF, Rica R, Tizian C, Viczenczova C, Khamina K, Faux T, Hainberger D, Penz T, Bosselut R, Bock C, Laiho A, Elo LL, Bergthaler A, Ellmeier W, Sakaguchi S. (2021). Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells. Front Immunol. 12:535039. doi: 10.3389/fimmu.2021.535039. eCollection 2021. PubMed link
2020
84. Hamminger P, Rica R, Ellmeier W. (2020) Histone deacetylases as targets in autoimmune and autoinflammatory diseases. Adv Immunol. 147:1-59. doi: 10.1016/bs.ai.2020.06.001 PubMed link
83. Redl E, Sheibani-Tezerji R, Cardona CJ, Hamminger P, Timelthaler G, Hassler MR, Zrimšek M, Lagger S, Dillinger T, Hofbauer L, Draganić K, Tiefenbacher A, Kothmayer M, Dietz CH, Ramsahoye BH, Kenner L, Bock C, Seiser C, Ellmeier W, Schweikert G, Egger G.(2020) Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis. Life Sci Alliance. 4(2):e202000794. doi: 10.26508/lsa.202000794 PubMed link
82. Hainberger D, Stolz V, Zhu C, Schuster M, Müller M, Hamminger P, Rica R, Waltenberger D, Alteneder M, Krausgruber T, Hladik A, Knapp S, Bock C, Trauner M, Farrar, MA and Ellmeier W. (2020) NCOR1 orchestrates transcriptional landscapes and effector functions of CD4+ T cells. Front Immunol. 11:579. doi: 10.3389/fimmu.2020.00579 PubMed link
81. Preglej T, Hamminger P, Luu M, Bulat T, Andersen L, Göschl L, Stolz V, Rica R, Sandner L, Waltenberger D, Tschismarov R, Faux T, Boenke T, Laiho A, Elo LL, Sakaguchi S, Steiner G, Decker T, Bohle B, Visekruna A, Bock C, Strobl B, Seiser C, Boucheron N, Ellmeier W. (2020). Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation. JCI Insight. 5(4):e133393. doi: 10.1172/jci.insight.133393. PubMed link
80. Frohner IE, Mudrak I, Schüchner S, Anrather D, Hartl M, Sontag JM, Sontag E, Wadzinski BE, Preglej T, Ellmeier W, Ogris E. (2020). PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation. Cell Reports, 30(9):3171-3182.e6. doi: 10.1016/j.celrep.2020.02.035 PubMed link
79. Göschl L, Preglej T, Boucheron N, Saferding V, Müller L, Platzer A, Hirahara K, Shih HY, Backlund J, Matthias P, Niederreiter B, Hladik A, Kugler M, Gualdoni GA, Scheinecker C, Knapp S, Seiser C, Holmdahl R, Tillmann K, Plasenzotti R, Podesser B, Aletaha D, Smolen JS, Karonitsch T, Steiner G, Ellmeier W, Bonelli M (2020). Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis. J Autoimmun. 108:102379. doi: 10.1016/j.jaut.2019.102379 PubMed link
2019
78. Andersen L, Gülich AF, Alteneder M, Preglej T, Orola MJ, Dhele N, Stolz V, Schebesta A, Hamminger P, Hladik A, Floess S, Krausgruber T, Faux T, Andrabi SBA, Huehn J, Knapp S, Sparwasser T, Bock C, Laiho A, Elo LL, Rasool O, Lahesmaa R, Sakaguchi S, Ellmeier W. (2019). The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells. Cell Rep. 29(13):4447-4459.e6. doi: 10.1016/j.celrep.2019.11.089 PubMed link
77. Orola MJ, Tizian C, Zhu C, Andersen L, Gülich AF, Alteneder M, Stojakovic T, Wiedermann U, Trauner M, Ellmeier W, Sakaguchi S. (2019) The zinc-finger transcription factor MAZR regulates iNKT cell subset differentiation. Cell Mol Life Sci. doi: 10.1007/s00018-019-03119-z. PubMed link
76. Gülich AF, Preglej T, Hamminger P, Alteneder M, Tizian C, Orola MJ, Muroi S, Taniuchi I, Ellmeier W, Sakaguchi S (2019). Differential Requirement of Cd8 Enhancers E8I and E8VI in Cytotoxic Lineage T Cells and in Intestinal Intraepithelial Lymphocytes. Front Immunol. 10:409. doi: 10.3389/fimmu.2019.00409. PubMed link
75. Ellmeier W, Seiser C. (2019). Author Correction: Histone deacetylase function in CD4+ T cells. Nat Rev Immunol. doi: 10.1038/s41577-019-0153-4. PubMed link
2018
74. Müller L, Hainberger D, Stolz V, Ellmeier W. (2018). NCOR1-a new player on the field of T cell development. Journal of Leukocyte Biology, 104(6):1061-1068. PubMed link
73. Ellmeier, W. and Seiser, C. (2018). Histone deacetylase function in CD4+ T cells. Nature Reviews Immunology, 18, 617-634. PubMed link
72. Forsthuber A, Lipp K, Andersen L, Ebersberger S, Graña-Castro O, Ellmeier W, Petzelbauer P, Lichtenberger BM, Loewe R (2018). CXCL5 as regulator of neutrophil function in cutaneous melanoma. J Invest Dermatol. 2018 Jul 13. pii: S0022-202X(18)32353-4. doi: 10.1016/j.jid.2018.07.006 PubMed link
71. Göschl L, Preglej T, Hamminger P, Bonelli M, Andersen L, Boucheron N, Gülich AF, Müller L, Saferding V, Mufazalov IA, Hirahara K, Seiser C, Matthias P, Penz T, Schuster M, Bock C, Waisman A, Steiner G, Ellmeier W. (2018). A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. Journal of Autoimmunity, 86:51-61. doi: 10.1016/j.jaut.2017.09.008. PubMed link
2017
70. Müller, L., Hainberger, D., Stolz, V., Hamminger, P., Hassan, H., Preglej, T., Boucheron, N., Sakaguchi, S., Wiegers, J.G., Villunger, A., Auwerx, J. and Ellmeier, W. (2017). The corepressor NCOR1 regulates the survival of single-positive thymocytes. Scientific Reports, Nov 7(1):15928. doi: 10.1038/s41598-017-15918-0. PubMed link
69. Nagy, L. and Ellmeier, W. (2017). Immunity meets metabolism and then they start talking. FEBS Lett. 591(19):2957-2958. doi: 10.1002/1873-3468.12857. PubMed link
68. de Bruijn MJ, Rip J, van der Ploeg EK, van Greuningen LW, Ta VT, Kil LP, Langerak AW, Rimmelzwaan GF, Ellmeier W, Hendriks RW, Corneth OB. (2017). Distinct and overlapping functions of Tec kinase and Btk in B cell receptor signaling. Journal of Immunology, 198(8):3058-3068. PubMed link
2016
67. Gualdoni GA, Mayer KA, Göschl L, Boucheron N, Ellmeier W, Zlabinger GJ. (2016). The AMP analog AICAR modulates the Treg/Th17 axis through enhancement of fatty acid oxidation. FASEB J. 30(11):3800-3809. PubMed link
66. Newman DM, Sakaguchi S, Lun A, Preston S, Pellegrini M, Khamina K, Bergthaler A, Nutt SL, Smyth GK, Voss AK, Thomas T, Ellmeier W, Belz GT, Allan RS. (2016). Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity. Cell Reports, 16(12):3311-21. PubMed link
2015
65. Sakaguchi, S., D. Hainberger, C. Tizian, H. Tanaka, T. Okuda, I. Taniuchi, and W. Ellmeier. (2015). MAZR and Runx Factors Synergistically Repress ThPOK during CD8+ T Cell Lineage Development. J Immunol. 195(6):2879-87. PubMed link
64. Schatzlmaier, P., Supper, V., Göschl, L., Zwizitz, A., Eckerstorger, P., Ellmeier, W., Huppa, J.B., Stockinger, H. (2015). Rapid multiplex analysis of lipid raft components with single-cell resolution. Science Signaling, 8(395):rs11. doi: 10.1126/scisignal.aac5584. PubMed link
63. Prochazkova, J, Sakaguchi, S., Owusu, M., Mazouzi, M., Wiedner, M., Velimezi, G., Moder, M., Turchinovich, G., Hladik, A., Gurnhofer, E., Hayday, A., Behrens, A., Knapp, S., Kenner. L., Ellmeier, W., Loizou, J.I. (2015). DNA Repair Cofactors ATMIN and NBS1 are Required to Suppress T Cell Activation. PLOS Genetics, 11(11):e1005645. PubMed link
62. Sakaguchi S, Hombauer M, Hassan H, Tanaka H, Yasmin N, Naoe Y, Bilic I, Moser MA, Hainberger D, Mayer H, Seiser C, Bergthaler A, Taniuchi I, Ellmeier W. (2015). A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells. J Leukoc Biol. 97(4):635-44. PubMed link
61. Manne BK, Badolia R, Dangelmaier C, Eble JA, Ellmeier W, Kahn M, Kunapuli SP. (2015). Distinct pathways regulate Syk activation downstream of ITAM and hemITAM receptors in platelets. J Biol Chem. 290(18):11557-68. PubMed link
60. Keskin N, Deniz E, Eryilmaz J, Un M, Batur T, Ersahin T, Cetin Atalay R, Sakaguchi S, Ellmeier W, Erman B. (2015). PATZ1 is a DNA damage responsive transcription factor that inhibits p53 function. Mol Cell Biol. 35(10):1741-53. PubMed link
59. Ellmeier, W. (2015). Molecular control of CD4+ T cell lineage plasticity and integrity. Int Immunopharmacol. 28(2):813-7. doi: 10.1016/j.intimp.2015.03.050. PubMed link
2014
58. Boucheron, N, Tschismarov, R, Göschl, L, Moser, Mirjam, Lagger, S, Sakaguchi, S, Winter, Lenz, F, Vitko, D., Breitwieser, FP, Haust, L, Hassan, H, Bennett, KL, Colinge, J, Schreiner, W, Matthias, P, Egawa, T, Taniuchi, I, Matthias, P, Seiser, C and Ellmeier, W. (2014). CD4 T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nature Immunology, 15(5):439-48. PubMed link
57. Ellmeier W, and Taniuchi I. The role of BTB-zinc finger transcription factors during T cell development and in the regulation of T cell-mediated immunity. (2014). Current Topics in Microbiology and Immunology. 381:21-49. doi: 10.1007/82_2014_374. PubMed link
56. Zwolanek F, Riedelberger M, Stolz V, Jenull S, Istel F, Köprülü AD, Ellmeier W, Kuchler K. (2014). The Non-receptor Tyrosine Kinase Tec Controls Assembly and Activity of the Noncanonical Caspase-8 Inflammasome. PLoS Pathog. 2014 ;10(12):e1004525. doi: 10.1371/journal.ppat.1004525. PubMed link
55. Tschismarov R, Firner S, Gil-Cruz C, Göschl L, Boucheron N, Steiner G, Matthias P, Seiser C, Ludewig B, Ellmeier W. (2014). HDAC1 controls CD8+ T cell homeostasis and antiviral response. PLoS One. 2014 Oct 21;9(10):e110576. doi: 10.1371/journal.pone.0110576. PubMed link
2013
54. Ellmeier, W., Haust, L., Tschismarov, R. (2013) Transcriptional control of CD4 and CD8 coreceptor expression during T cell development. Cellular and Molecular Life Sciences, 10.1007/s00018-013-1393-2. PubMed link
53. Köprülü, A.D., Kastner, R., Wienerroither, S., Lassnig, S., Putz, E.M., Majer, O., Reutterer, B., Sexl, V., Kuchler, K., Müller, M., Decker, W. and Ellmeier W. (2013). The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection. PLoS One, 2013;8(3):e60476. PubMed link
52. Abramova A, Sakaguchi S, Schebesta A, Hassan H, Boucheron N, Valent P, Roers A, Ellmeier W. (2013). The transcription factor MAZR preferentially acts as a transcriptional repressor in mast cells and plays a minor role in the regulation of effector functions in response to Fc-epsilonRI stimulation. PLoS One. 8(10):e77677. doi: 10.1371/journal.pone.0077677. eCollection 2013. PubMed link
51. Mucida M, Husain MM, Muroi S, van Wijk F, Shinnakasu R, Naoe Y, Reis BS, Huang Y, Lambolez F, Docherty M, Attinger A, Shui JW, Kim G, Lena CJ, Sakaguchi S, Miyamoto C, Wang P, Atarashi K, Park Y, Nakayama T, Honda K, Ellmeier, W., Kronenberg M, Taniuchi I and Cheroutre, H. (2013). Transcriptional Reprogramming of Mature CD4 T helper Cells generates distinct MHC class II restricted Cytotoxic T Lymphocytes. Nature Immunology, 14(3):281-9. PubMed link
2012
50. Boucheron N and Ellmeier W. (2012). The role of Tec family kinases in the regulation of T-helper-cell differentiation. Int Rev Immunol. 2:133-54.PubMed link
2011
49. Hassan, H., Sakaguchi, S., Tenno, M., Kopf, A., Boucheron, N. Carpenter, A., Egawa, T., Taniuchi, I. Ellmeier, W. (2011). Cd8 enhancer E8I and Runx factors regulate CD8? expression in activated CD8+ T cells. PNAS. 108(45):18330-5.PubMed link
48. Taniuchi, I. and Ellmeier, W. (2011). Transcriptional and epigenetic regulation of CD4/CD8 lineage choice. Adv. Immunol.,110:71-110. PubMed link
47. Collins A, Hewitt SL, Chaumeil J, Sellars M, Micsinai M, Allinne J, Parisi F, Nora EP, Bolland DJ, Corcoran AE, Kluger Y, Bosselut R, Ellmeier W, Chong MM, Littman DR, Skok JA. (2011). RUNX Transcription Factor-Mediated Association of Cd4 and Cd8 Enables Coordinate Gene Regulation. Immunity, 34(3):303-14. PubMed link
46. Ormsby, T.,Schlecker, E., Ferdin, J., Tessarz, A.S., Angelisova, P. , Köprülü, A.D., Borte, M., Warnatz, K., Schulze, I., Ellmeier, W. Horejsi, V. and Cerwenka, A. (2011). Btk is a positive regulator in the TREM-1/DAP12 signaling pathway. Blood, 118(4):936-45. PubMed link
45. Todoric, J., Strobl, B., Boucheron, B., Bayer, M., Bilban, M. Ellmeier, W., M?ller, M. Wagner, O., Pospisilik, J.A. Esterbauer, H. (2011). Cross-talk between Interferon-gamma and Hedgehog signaling regulates adipogenesis. Diabetes, 60(6):1668-76. PubMed link
44. Xanthos, D.N., Gaderer, S., Drdla, R., Nuro, E., Abramova, A., Ellmeier, W., Sandkühler, J. (2011). Central nervous system mast cells in peripheral inflammation. Mol Pain, 7:42. PubMed link
43. Ellmeier W, Abramova A, Schebesta A. (2011). Tec family kinases: Regulation of Fc-epsilon RI-mediated mast cell activation. FEBS J. 278(12):1990-2000. PubMed link
2010
42. Sakaguchi S, Hombauer M, Bilic I, Naoe Y, Schebesta A, Taniuchi I, Ellmeier W. (2010). The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes.
Nat Immunol. 11(5):442-8. PubMed link
41. Grausenburger, R, Bilic, I., Boucheron, N., Zupkovitz, G., El-Housseiny, L., Tschismarov, R., Zhang, Y., Rembold, M., Gaisberger, M., Hartl, A., Epstein, M.M., Matthias, P., Seiser, C., Ellmeier, W. (2010). Conditional deletion of HDAC1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. Journal of Immunology, 185(6): 3489-97. PubMed link
40. Boucheron N, Sharif O, Schebesta A, Croxford A, Raberger J, Schmidt U, Vigl B, Bauer J, Bankoti R, Lassmann H, Epstein MM, Knapp S, Waisman A, Ellmeier W. (2010). The Protein Tyrosine Kinase Tec Regulates a CD44highCD62L- Th17 Subset. Journal of Immunology, 185(9): 5111-9. PubMed link
2009
39. Köprülü, A.D. and Ellmeier, W. (2009). The Role of Tec Family Kinases in Mononuclear Phagocytes. Critical Reviews in Immunology, 29(4):317-33.PubMed link
38. Schmidt, U., Abramova, A., Boucheron, N., Eckelhart, E., Schebesta, A., Bilic, I., Kneidinger, M., Unger, B., Hammer, M., Sibilia, M, Valent, P. and Ellmeier, W. (2009). The protein tyrosine kinase Tec regulates mast cell function. European Journal of Immunology, 39(11): 3228-28. PubMed link
37. Blomberg KE, Boucheron N, Lindvall JM, Yu L, Raberger J, Berglöf A, Ellmeier W, Smith CE. Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells. (2009). BMC Genomics, 10, 233. PubMed link
2008
36. Raberger, J., Schebesta, A., Sakaguchi, S., Boucheron, N., Blomber, K.M., Berglöf, A., Kolbe, T., Smith, C.I.E., Rülicke, T., and Ellmeier, W. (2008). The Transcriptional Regulator PLZF Induces the Development of CD44-High Memory-Phenotype T Cells. PNAS, 105, 17919-24. PubMed link
35. Raberger, J., Boucheron , N. , Sakaguchi, S., Penninger, J.M. and Ellmeier , W. (2008). Impaired T cell development in the absence of Vav1 and Itk. European Journal of Immunology, 38, 3530-42. PubMed link
34. Melcher, M., Unger, B., Schmidt, U., Rajantie, I.A., Alitalo, K., and Ellmeier, W. (2008). Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. 2008. The Journal of Immunology, 180, 8048-56. PubMed link
33. Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H. (2008). Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell, 132, 794-806. PubMed link
32. Kneidinger M, Schmidt U, Rix U, Gleixner KV, Vales A, Baumgartner C, Lupinek C, Weghofer M, Bennett KL, Herrmann H, Schebesta A, Thomas WR, Vrtala S, Valenta R, Lee FY, Ellmeier W, Superti-Furga G, Valent P. (2008). The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood, 111, 3097-107. PubMed link
2007
31. Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A. (2007). 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nature Immunology, 8, 1049-59. PubMed link
30. Hantschel O, Rix U, Schmidt U, Burckstummer T, Kneidinger M, Schutze G, Colinge J, Bennett KL, Ellmeier W, Valent P, Superti-Furga G. (2007). The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. PNAS. 104, 13283-8. PubMed link
29. Bilic, I., and Ellmeier, W. (2007). The role of BTB domain-containing zinc finger proteins in T cell development and function. Immunol Lett. 108, 1-9. PubMed link
28. Taschner, S., Koesters, C., Platzer, B., Jorgl, A., Ellmeier, W., Benesch, T., Strobl, H. Downregulation of RXR{alpha} expression is essential for neutrophil development from granulocyte/monocyte progenitors. (2007). Blood, 109, 971-9. PubMed link
27. Koesters, C., Unger, B. Bilic, I., Bluml, S., Lichtenberger, B., Schreiber, M., Stockl, J. and Ellmeier, W. (2007). Regulation of dendritic cell differentiation, maturation and subset distribution by the zinc finger protein CTCF. Immunology Letters, 109, 165-74. PubMed link
2006
26. Bilic, I., Koesters, C., Unger, B., Sekimata, M., Hertweck, A., Maschek, R., Wilson, C.B. and Ellmeier, W. (2006).
Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nature Immunology, 7, 393-400. PubMed link
2005
25. Sarafova, S.D., Erman, B., Yu, O., Van Laethem, F., Guinter, T., Sharrow, S.O., Feigenbaum, L., Wildt, F.L., Ellmeier, W. and Singer, A. (2005). Transcriptional Modulation of Coreceptor Expression during Positive Selection Dictates Lineage Fate Independently of TCR Specificity and Coreceptor Protein Identity, Immunity, 23:75-87. PubMed link
24. Marquez, M.E., Ellmeier, W ., Sanchez-Guajardo, V., Freitas, A.A., Acuto, O. and Di Bartolo, V. (2005). CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens. The Journal of Immunology, J Immunol., 175(11):3788-97. PubMed link
23. Feik,
N., Bilic, I., Tinhofer, J., Unger, B., Littman, D.R. and Ellmeier,
W. (2005). Functional and Molecular Analysis of the Double-Positive
Stage-specific CD8 Enhancer E8III During Thymocyte Development.
J Immunol., 174(3):1513-24. PubMed link
2004
22. Yu
PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae
K, Ellmeier W, Witte ON, Rawlings, D.R. (2004). Sustained correction
of B cell development and function in a murine model of X-linked
agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
Blood,
104(5):1281-90. PubMed link
21. Madakamutil
LT, Christen U, Lena CJ, Wang-Zhu Y, Attinger A, Sundarrajan M,
Ellmeier W, von Herrath MG, Jensen P, Littman DR, Cheroutre H. (2004).
CD8alphaalpha mediated survival and differentiation of CD8 memory
T cell precursors. Science, 304, 590-93. PubMed link
20. Taniuchi,
I., Ellmeier, W., Littman, D.R. (2004). The CD4/CD8 Lineage Choice:
New Insights into Epigenetic Regulation During T Cell Development.
Adv. Immunology. Vol 83, 55-89. PubMed link
19. Schmidt,
U., Boucheron, N., Unger, B., Ellmeier, W. (2004). The role of Tec
family kinases in myeloid cells. Int Arch of Allergy Immunol., 134,
65-78. PubMed link
18. Schmidt,
U., Van Den Akker, E., Parren-Van Amelsvoort ,M., Litos, G., De
Bruijn , M., Gutierrez, L., Hendriks, R.W., Ellmeier, W., Lowenberg,
B., Beug, H,. Von Lindern, M. (2004). Btk Is Required for an Efficient
Response to Erythropoietin and for SCF-controlled Protection against
TRAIL in Erythroid Progenitors. J Exp Med, 199, 785-795. PubMed link
2003
17. Atkinson,
B.T., Ellmeier, W., Watson, S.P. (2003). Tec regulates platelet activation
by GPVI in the absence of Btk. Blood, 102, 3592-9. PubMed link
2002
16. Kioussis,
D., Ellmeier, W. (2002). Chromatin and CD4, CD8A and CD8B gene expression
during thymic differentiation. Nat Rev Immunol, 2, 909-19. PubMed link
15. Ellmeier,
W., Sunshine, M.J., Maschek, R., Littman, D.R. (2002). Combined
deletion of CD8 locus cis-regulatory elements affects initiation
but not maintenance of CD8 expression. Immunity, 16, 623-34. PubMed link
14. Keppler,
O.T., Welte, F.J., Ngo, T.A., Chin, P.S., Patton, K.S., Tsou, C.L.,
Abbey, N.W., Sharkey, M.E., Grant, R.M., You, Y., Scarborough, J.D.,
Ellmeier, W., Littman, D.R., Stevenson, M., Charo, I.F., Herndier,
B.G., Speck, R.F., Goldsmith, M.A. (2002). Progress toward a human
CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency
virus type 1. Journal of Experimental Medicine, 195, 719-36. PunMed link
2001
13. Donnadieu,
E., Lang, V., Bismuth, G., Ellmeier, W., Acuto, O., Michel, F.,
Trautmann, A. (2001). Differential roles of Lck and Itk in T cell
response to antigen recognition revealed by calcium imaging and
electron microscopy. Journal of Immunology, 166, 5540-9. PubMed link
1996 - 2000 (publications from postdoctoral studies of W.E.)
12. Ellmeier, W., Jung, S., Sunshine, M.J., Hatam, F.,
Xu, Y, Baltimore, D., Mano, H. and Littman, D.R. (2000). Severe
B Cell Deficiency in Mice Lacking the Tec Kinase Family Members
Tec and Btk. The Journal of Experimental Medicine, 192, 1611-24. PubMed link
11. Sun,
Z., Arendt, C.W., Ellmeier, W., Schaeffer, E.M., Sunshine, M.J.,
Gandhi, L., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg,
P.L., Littman, D.R. (2000). PKC-theta is required for TCR-induced
NF-kappaB activation in mature but not immature T lymphocytes. Nature,
404, 402-7. PubMed link
10. Ellmeier, W., Sawada, S. and Littman, D.R. (1999). The Regulation
of CD4 and CD8 Coreceptor Gene Expression During T Cell Development.
Annual Reviews of Immunology, 17, 523-554. PubMed link
9. Ellmeier, W., Sunshine, M.J., Losos, K. and Littman, D.R.
(1998). Multiple Developmental Stage-Specific Enhancers Regulate
CD8 Expression In Developing Thymocytes and in Thymus-Independent
T Cells. Immunity, 9, 485-496. PubMed link
8. Ellmeier, W., Sunshine, M.J., Losos, K., Hatam, F.
and Littman, D.R. (1997). An Enhancer that Directs Lineage-Specific
Expression of CD8 in Positively Selected Thymocytes and Mature T
cells. Immunity, 7, 537-547. PubMed link
7. Deng,
H., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M.,
Di Marzio, P., Marmon, S., Sutton, R.E., Hill, C.M., Davis, C.B.,
Peiper, S.C., Schall, T.J., Littman, D.R., Landau, N.R. (1996).
Protein Identification of a major co-receptor for primary isolates
of HIV-1. Nature, 381, 661-6. PubMed link
1992 - 1995 (publications from PhD studies of W.E.)
6. Ellmeier, W., Barnas, C., Kobrna, A., Kleiner, E., Kurzbauer, R. and Weith, A. (1996). Cloning and Characterization of CpG islands of the Human Chromosome 1p36 Region. Genomics, 32, 155-158. PubMed link
5. Ellmeier, W. and Weith, A. (1995). Expression of Id3 during murine embryonic development. Developmental Dynamics, 203, 163-173. PubMed link
4. Barnas, C., Kleiner, E., Ellmeier, W., Henn, T., Brunner, C., Stapelton, P. and Weith, A. (1995). Megabasepair-sized grouped sets of microclones: a first generation physical map of chromosome 1pter - p35. Genomics, 29, 607-615. PubMed link
3. Aguzzi, A., Ellmeier, W. and Weith, A. (1992). Dominant and recessive molecular changes in neuroblastomas. Brain Pathology, 2, 195-208. PubMed link
2. Ellmeier, W., Aguzzi, A., Kleiner, E., Kurzbauer, R. and Weith, A. (1992). Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development. EMBO J., 11, 2563-2571. PubMed link
1991 (publications from master thesis of W.E.)
1. Eckner, R., Ellmeier, W. and Birnstiel, M.L. (1991). Mature mRNA 3' end formation stimulates RNA export from the nucleus. EMBO J., 10, 3513-3522. PubMed link