recent publications

2009

Köprülü, A.D. and Ellmeier, W. The Role of Tec Family Kinases in Mononuclear Phagocytes. 2009. Critical Reviews in Immunology, in press.

Schmidt, U., Abramova, A., Boucheron, N., Eckelhart, E., Schebesta, A., Bilic, I., Kneidinger, M., Unger, B., Hammer, M., Sibilia, M, Valent, P. and Ellmeier, W. The protein tyrosine kinase Tec regulates mast cell function. 2009. European Journal of Immunology, in press.

Blomberg KE, Boucheron N, Lindvall JM, Yu L, Raberger J, Berglöf A, Ellmeier W, Smith CE. Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells. 2009. BMC Genomics, 10, 233.

2008

Raberger, J, Schebesta, A., Sakaguchi, S., Boucheron, N., Blomberg , K.M. , Berglöf , A. , Kolbe , T., Smith , C.I.E. , Rülicke , T. and Ellmeier, W. The Transcriptional Regulator PLZF Induces the Development of CD44-High Memory-Phenotype T Cells. 2008. PNAS, 105, 17919-24.

Raberger, J., Boucheron , N. , Sakaguchi, S., Penninger, J.M. and Ellmeier , W. Impaired T cell development in the absence of Vav1 and Itk. 2008. European Journal of Immunology, 38, 3530-42.

Melcher, M., Unger, B., Schmidt, U., Rajantie, I.A., Alitalo, K., and Ellmeier, W. 2008. Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. 2008. The Journal of Immunology, 180, 8048-56.

Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H. 2008. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell, 132, 794-806.

Kneidinger M, Schmidt U, Rix U, Gleixner KV, Vales A, Baumgartner C, Lupinek C, Weghofer M, Bennett KL, Herrmann H, Schebesta A, Thomas WR, Vrtala S, Valenta R, Lee FY, Ellmeier W, Superti-Furga G, Valent P. 2008. The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood, 111, 3097-107.


2007

Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A. (2007). 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nature Immunology, 8, 1049-59.

Hantschel O, Rix U, Schmidt U, Burckstummer T, Kneidinger M, Schutze G, Colinge J, Bennett KL, Ellmeier W, Valent P, Superti-Furga G. (2007). The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. PNAS. 104, 13283-8.

Bilic, I., and Ellmeier, W. (2007). The role of BTB domain-containing zinc finger proteins in T cell development and function. Immunol Lett. 108, 1-9.

Taschner, S., Koesters, C., Platzer, B., Jorgl, A., Ellmeier, W., Benesch, T., Strobl, H. Downregulation of RXR{alpha} expression is essential for neutrophil development from granulocyte/monocyte progenitors. (2007). Blood, 109, 971-9.

Koesters, C., Unger, B. Bilic, I., Bluml, S., Lichtenberger, B., Schreiber, M., Stockl, J. and Ellmeier, W. 2007. Regulation of dendritic cell differentiation, maturation and subset distribution by the zinc finger protein CTCF. Immunology Letters, 109, 165-74.

2006

Bilic, I., Koesters, C., Unger, B., Sekimata, M., Hertweck, A., Maschek, R., Wilson, C.B. and Ellmeier, W. (2006). Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR. Nature Immunology, 7, 393-400.

2005

Sarafova, S.D., Erman, B., Yu, O., Van Laethem, F., Guinter, T., Sharrow, S.O., Feigenbaum, L., Wildt, F.L., Ellmeier, W. and Singer, A. (2005). Transcriptional Modulation of Coreceptor Expression during Positive Selection Dictates Lineage Fate Independently of TCR Specificity and Coreceptor Protein Identity, Immunity, 23:75-87.

Marquez, M.E., Ellmeier, W ., Sanchez-Guajardo, V., Freitas, A.A., Acuto, O. and Di Bartolo, V. (2005) CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens. The Journal of Immunology, J Immunol., 175(11):3788-97.

Feik, N., Bilic, I., Tinhofer, J., Unger, B., Littman, D.R. and Ellmeier, W. (2005). Functional and Molecular Analysis of the Double-Positive Stage-specific CD8 Enhancer E8III During Thymocyte Development. J Immunol., 174(3):1513-24.

2004

Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings, D.R. (2004). Sustained correction of B cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. Blood, 104(5):1281-90.

Madakamutil LT, Christen U, Lena CJ, Wang-Zhu Y, Attinger A, Sundarrajan M, Ellmeier W, von Herrath MG, Jensen P, Littman DR, Cheroutre H. (2004). CD8alphaalpha mediated survival and differentiation of CD8 memory T cell precursors. Science, 304, 590-93.

Taniuchi, I., Ellmeier, W., Littman, D.R. (2004) The CD4/CD8 Lineage Choice: New Insights into Epigenetic Regulation During T Cell  Development. Adv. Immunology. Vol 83, 55-89.

Schmidt, U., Boucheron, N., Unger, B., Ellmeier, W. (2004) The role of Tec family kinases in myeloid cells. Int Arch of Allergy Immunol., 134, 65-78.

Schmidt, U., Van Den Akker, E., Parren-Van Amelsvoort ,M., Litos, G., De Bruijn , M., Gutierrez, L., Hendriks, R.W., Ellmeier, W., Lowenberg, B., Beug, H,. Von Lindern, M. (2004). Btk Is Required for an Efficient Response to Erythropoietin and for SCF-controlled Protection against TRAIL in Erythroid Progenitors. J Exp Med, 199, 785-795.

2003

Atkinson, B.T., Ellmeier, W., Watson, S.P. (2003) Tec regulates platelet activation by GPVI in the absence of Btk. Blood, 102, 3592-9.

2002

Kioussis, D., Ellmeier, W. (2002). Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation. Nat Rev Immunol, 2, 909-19.

Ellmeier, W., Sunshine, M.J., Maschek, R., Littman, D.R. (2002). Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity, 16, 623-34.

Keppler, O.T., Welte, F.J., Ngo, T.A., Chin, P.S., Patton, K.S., Tsou, C.L., Abbey, N.W., Sharkey, M.E., Grant, R.M., You, Y., Scarborough, J.D., Ellmeier, W., Littman, D.R., Stevenson, M., Charo, I.F., Herndier, B.G., Speck, R.F., Goldsmith, M.A. (2002). Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1. Journal of Experimental Medicine, 195, 719-36.

2001

Donnadieu, E., Lang, V., Bismuth, G., Ellmeier, W., Acuto, O., Michel, F., Trautmann, A. (2001). Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy. Journal of Immunology, 166, 5540-9.

2000

Ellmeier, W., Jung, S., Sunshine, M.J., Hatam, F., Xu, Y, Baltimore, D., Mano, H. and Littman, D.R. (2000). Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk. The Journal of Experimental Medicine, 192, 1611-24.

Sun, Z., Arendt, C.W., Ellmeier, W., Schaeffer, E.M., Sunshine, M.J., Gandhi, L., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg, P.L., Littman, D.R. (2000). PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature, 404, 402-7.

1996-1999

Ellmeier, W., Sawada, S. and Littman, D.R. (1999). The Regulation of CD4 and CD8 Coreceptor Gene Expression During T Cell Development. Annual Reviews of Immunology, 17, 523-554.

Ellmeier, W., Sunshine, M.J., Losos, K. and Littman, D.R. (1998). Multiple Developmental Stage-Specific Enhancers Regulate CD8 Expression In Developing Thymocytes and in Thymus-Independent T Cells. Immunity, 9, 485-496.

Ellmeier, W., Sunshine, M.J., Losos, K., Hatam, F. and Littman, D.R. (1997). An Enhancer that Directs Lineage-Specific Expression of CD8 in Positively Selected Thymocytes and Mature T cells. Immunity, 7, 537-547.

Deng, H., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R.E., Hill, C.M., Davis, C.B., Peiper, S.C., Schall, T.J., Littman, D.R., Landau, N.R. (1996). Protein Identification of a major co-receptor for primary isolates of HIV-1. Nature, 381, 661-6