!! Postdoc position available !! download information <here>
Molecular Regulation of T Cell-mediated Immunity
T lymphocytes (T cells) are key cellular players in the regulation and execution of immune responses in response to foreign pathogens and also against endogenous danger such as cancer cells. Our long-term research interest is to characterize molecular mechanisms that regulate the development, differentiation and effector function of T lymphocytes. With our studies we aim to provide important and medical-relevant insight into the regulation of T cell-mediated immunity. In ongoing studies we address the following research topics:
• The role of histone deacetylases in the regulation of T cell-mediated immunity
• Transcriptional control of T cell development
• Regulation of peripheral T cell function and maintenance of T cell lineage identity and integrity
The experimental strategies to address our research interests include multi-color flow-cytometry, a variety of immunological tools, biochemical and molecular approaches, retroviral-mediated gene transduction into hematopoietic stem cells, next generation sequencing and mouse molecular genetics tools.
Research groups at the Division of Immunobiology
• Nicole Boucheron
• Wilfried Ellmeier (head of the division)
• Shinya Sakaguchi
News
++ 09/2022 - The SFB F70 organizes a symposium on histone deacetylases (19-20.9.2022): from basic research to clinical application chromatin & epigenetics * HDAC biology and function * dissecting T cell-mediated immunity using OMICS approaches * clinical application of epigenetic inhibitors
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