AF001: Helix-loop-helix DNA-binding domain

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This domain is part of a wide range of eukaryotic transcription factors [1].

Allergens from this family

An allergen from the mould Fusarium culmorum contains this domain [2].



  1. Jones S:
    An overview of the basic helix-loop-helix proteins.
    Genome Biol 2004, 5, 226. [PubMed] [Full Text]
  2. Hoff M, Ballmer-Weber BK, Niggemann B, Cistero-Bahima A, San Miguel-Moncin M, Conti A, Haustein D, Vieths S:
    Molecular cloning and immunological characterisation of potential allergens from the mould Fusarium culmorum.
    Mol Immunol 2003, 39, 965-75. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00010 Helix-loop-helix DNA-binding domain -

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .