AF002: Heat shock protein Hsp70

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Hsp70 proteins are ubiquitous chaperones that catalyze protein folding driven by hydrolysis of ATP [1].

Allergens from this family

Allergens belonging to the Hsp70 family are found in a heterogeneous range of sources. Several fungal allergens belong to this family such as Mala s 10 from Malassezia sympodialis [2] and Alt a 3 from Alternaria alternata. In addition, the hazel pollen allergen Cor a 10 [3] and Der f 28 from the mite Dermatophagoides farinae [4] belong to this family.



  1. Mayer MP, Bukau B:
    Hsp70 chaperones: cellular functions and molecular mechanism.
    Cell Mol Life Sci 2005, 62, 670-84. [PubMed] [Full Text]
  2. Andersson A, Rasool O, Schmidt M, Kodzius R, Fluckiger S, Zargari A, Crameri R, Scheynius A:
    Cloning, expression and characterization of two new IgE-binding proteins from the yeast Malassezia sympodialis with sequence similarities to heat shock proteins and manganese superoxide dismutase.
    Eur J Biochem 2004, 271, 1885-94. [PubMed] [Full Text]
  3. Gruehn S, Suphioglu C, O'Hehir RE, Volkmann D:
    Molecular cloning and characterization of hazel pollen protein (70 kD) as a luminal binding protein (BiP): a novel cross-reactive plant allergen.
    Int Arch Allergy Immunol 2003, 131, 91-100. [PubMed] [Full Text]
  4. Aki T, Fujikawa A, Wada T, Jyo T, Shigeta S, Murooka Y, Oka S, Ono K:
    Cloning and expression of cDNA coding for a new allergen from the house dust mite, Dermatophagoides farinae: homology with human heat shock cognate proteins in the heat shock protein 70 family.
    J Biochem 1994, 115, 435-40. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00012 Hsp70 protein CL0108 Actin-like ATPase Superfamily

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .