AF002: Heat shock protein Hsp70
Hsp70 proteins are ubiquitous chaperones that catalyze protein folding driven by hydrolysis of ATP .
Allergens from this family
Allergens belonging to the Hsp70 family are found in a heterogeneous range of sources. Several fungal allergens belong to this family such as Mala s 10 from Malassezia sympodialis  and Alt a 3 from Alternaria alternata. In addition, the hazel pollen allergen Cor a 10  and Der f 28 from the mite Dermatophagoides farinae  belong to this family.
Hsp70 chaperones: cellular functions and molecular mechanism.
Cell Mol Life Sci 2005, 62, 670-84. [PubMed] [Full Text]
Cloning, expression and characterization of two new IgE-binding proteins from the yeast Malassezia sympodialis with sequence similarities to heat shock proteins and manganese superoxide dismutase.
Eur J Biochem 2004, 271, 1885-94. [PubMed] [Full Text]
Molecular cloning and characterization of hazel pollen protein (70 kD) as a luminal binding protein (BiP): a novel cross-reactive plant allergen.
Int Arch Allergy Immunol 2003, 131, 91-100. [PubMed] [Full Text]
Cloning and expression of cDNA coding for a new allergen from the house dust mite, Dermatophagoides farinae: homology with human heat shock cognate proteins in the heat shock protein 70 family.
J Biochem 1994, 115, 435-40. [PubMed]
Links to Pfam
Family-defining Pfam domains (at least one of these domains is present in each family member):
Actin-like ATPase Superfamily
Links to Wikipedia
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