AF003: Animal Kunitz serine protease inhihibitor

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

These protease inhibitors belong to the MEROPS family I2 and inhibit serine proteases from the family S2. The type example for this family is aprotinin (bovine pancreatic trypsin inhibitor) [1].

Allergens from this family

The family contains only a single allergen: Ani s 1, a major allergen from the fish parasite Anisakis simplex [2].



  1. Ascenzi P, Bocedi A, Bolognesi M, Spallarossa A, Coletta M, De Cristofaro R, Menegatti E:
    The bovine basic pancreatic trypsin inhibitor (Kunitz inhibitor): a milestone protein.
    Curr Protein Pept Sci 2003, 4, 231-51. [PubMed]
  2. Moneo I, Caballero ML, Gomez F, Ortega E, Alonso MJ:
    Isolation and characterization of a major allergen from the fish parasite Anisakis simplex.
    J Allergy Clin Immunol 2000, 106, 177-82. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -

Additional Pfam domains found in some family members:

Pfam domain Pfam clan
PF14625 Lustrin, cysteine-rich repeated domain -

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .