AF004: Eukaryotic aspartyl protease

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Aspartyl proteases (also named acid protease) contain two conserved aspartate residues in their catalytic centers [1]. This family includes pepsins, cathepsins, and renins.

Allergens from this family

Allergens belonging to this family include the major cockroach allergen Bla g 2 [2] and several fungal allergens. In addition, the γ-conglutin seed storage proteins from lupine seeds belong to this family [3].



  1. Szecsi PB:
    The aspartic proteases.
    Scand J Clin Lab Invest Suppl 1992, 210, 5-22. [PubMed]
  2. Pomes A, Chapman MD, Vailes LD, Blundell TL, Dhanaraj V:
    Cockroach allergen Bla g 2: structure, function, and implications for allergic sensitization.
    Am J Respir Crit Care Med 2002, 165, 391-7. [PubMed] [Full Text]
  3. Klos P, Poreba E, Springer E, Lampart-Szczapa E, Gozdzicka Jozefiak A:
    Identification of a specific IgE-binding protein from narrow-leafed lupin (L. Angustifolius) seeds.
    J Food Sci 2010, 75, H39-43. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00026 Eukaryotic aspartyl protease CL0129 Peptidase clan AA
PF07966 A1 Propeptide -
PF14541 Xylanase inhibitor C-terminal CL0129 Peptidase clan AA
PF14543 Xylanase inhibitor N-terminal CL0129 Peptidase clan AA

Links to Wikipedia


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