AF006: Cytochrome c

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Cytochrome c is an electron transfer protein having one or several haem c groups bound to the protein by one or two thioether bonds involving sulphydryl groups of cysteine residues. The fifth haem iron ligand is always provided by a histidine residue. Cytochrome c possesses a wide range of properties and functions in a large number of different redox processes.

Allergens from this family

Cur l 3, a cytochrome c from the fungus Curvularia lunata was identified as an allergen [1]. In addition, cytochromes c were proposed to constitute a group of grass pollen allergens (group 10) [2].



  1. Sharma V, Singh BP, Gaur SN, Arora N:
    Molecular and immunological characterization of cytochrome c: a potential cross-reactive allergen in fungi and grasses.
    Allergy 2008, 63, 189-97. [PubMed] [Full Text]
  2. Andersson K, Lidholm J:
    Characteristics and immunobiology of grass pollen allergens.
    Int Arch Allergy Immunol 2003, 130, 87-107. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00034 Cytochrome c CL0318 Cytochrome c superfamily

Links to Wikipedia


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