AF007: EF hand family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

A wide range of calcium-binding proteins share a conserved domain consisting of a 12 residue calcium-binding loop flanked on both sides by α-helices of 12 residues in length. The biological functions of these proteins can be divided into two classes: signaling and calcium buffering or transport. Signaling proteins such as calmodulin and troponin C undergo a conformational change upon calcium binding [1].

Allergens from this family

Several groups of allergens were found within this family.

The IgE binding capacity of some EF hand-containing allergens was shown to be calcium-dependent.



  1. Gifford JL, Walsh MP, Vogel HJ:
    Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs.
    Biochem J 2007, 405, 199-221. [PubMed] [Full Text]
  2. Okada T, Sasaki Y, Ohta R, Onozuka N, Toriyama K:
    Expression of Bra r 1 gene in transgenic tobacco and Bra r 1 promoter activity in pollen of various plant species.
    Plant Cell Physiol 2000, 41, 757-66. [PubMed]
  3. Wopfner N, Gruber P, Wallner M, Briza P, Ebner C, Mari A, Richter K, Vogel L, Ferreira F:
    Molecular and immunological characterization of novel weed pollen pan-allergens.
    Allergy 2008, 63, 872-81. [PubMed] [Full Text]
  4. Ledesma A, Barderas R, Westritschnig K, Quiralte J, Pascual CY, Valenta R, Villalba M, Rodriguez R:
    A comparative analysis of the cross-reactivity in the polcalcin family including Syr v 3, a new member from lilac pollen.
    Allergy 2006, 61, 477-84. [PubMed] [Full Text]
  5. Berchtold MW, Brinkmeier H, Muntener M:
    Calcium ion in skeletal muscle: its crucial role for muscle function, plasticity, and disease.
    Physiol Rev 2000, 80, 1215-65. [PubMed]
  6. Kuehn A, Swoboda I, Arumugam K, Hilger C, Hentges F:
    Fish allergens at a glance: variable allergenicity of parvalbumins, the major fish allergens.
    Front Immunol 2014, 5, 179. [PubMed] [Full Text]
  7. Hindley J, Wunschmann S, Satinover SM, Woodfolk JA, Chew FT, Chapman MD, Pomes A:
    Bla g 6: a troponin C allergen from Blattella germanica with IgE binding calcium dependence.
    J Allergy Clin Immunol 2006, 117, 1389-95. [PubMed] [Full Text]
  8. Pedrosa M, Boyano-Martinez T, Garcia-Ara C, Quirce S:
    Shellfish Allergy: a Comprehensive Review.
    Clin Rev Allergy Immunol 2015, 49, 203-16. [PubMed] [Full Text]
  9. Gao Y, Gillen CM, Wheatly MG:
    Molecular characterization of the sarcoplasmic calcium-binding protein (SCP) from crayfish Procambarus clarkii.
    Comp Biochem Physiol B Biochem Mol Biol 2006, 144, 478-87. [PubMed] [Full Text]
  10. Ayuso R, Grishina G, Ibanez MD, Blanco C, Carrillo T, Bencharitiwong R, Sanchez S, Nowak-Wegrzyn A, Sampson HA:
    Sarcoplasmic calcium-binding protein is an EF-hand-type protein identified as a new shrimp allergen.
    J Allergy Clin Immunol 2009, 124, 114-20. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00036 EF hand CL0220 EF-hand like superfamily
PF01023 S-100/ICaBP type calcium binding domain CL0220 EF-hand like superfamily
PF13202 EF hand CL0220 EF-hand like superfamily
PF13405 EF-hand domain CL0220 EF-hand like superfamily
PF13499 EF-hand domain pair CL0220 EF-hand like superfamily
PF13833 EF-hand domain pair CL0220 EF-hand like superfamily

Additional Pfam domains found in some family members:

Pfam domain Pfam clan
PF01221 Dynein light chain type 1 -

Links to Wikipedia


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