AF008: Intermediate filament protein

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Intermediate filaments (IF) are proteins which are primordial components of the cytoskeleton and the nuclear envelope. IF proteins are members of a very large multigene family which has been subdivided into five major subgroups. While IF proteins are evolutionary and structurally related, they have limited sequence similarities [1].

Allergens from this family

Human cytokeratin 6A (Hom s 5) was described to be an autoallergen for atopic dermatitis patients [2].



  1. Omary MB, Coulombe PA, McLean WH:
    Intermediate filament proteins and their associated diseases.
    N Engl J Med 2004, 351, 2087-100. [PubMed] [Full Text]
  2. Natter S, Seiberler S, Hufnagl P, Binder BR, Hirschl AM, Ring J, Abeck D, Schmidt T, Valent P, Valenta R:
    Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients.
    FASEB J 1998, 12, 1559-69. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00038 Intermediate filament protein -
PF16208 Keratin type II head -

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .