AF011: Eukaryotic elongation factor 1

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Eukaryotic elongation factor 1 (EF-1) is responsible for the GTP-dependent binding of aminoacyl-tRNAs to the ribosomes. It is composed of four subunits. The β and δ chains are highly similar proteins that both stimulate the exchange of GDP bound to the α chain for GTP [1]. On their N-termini, they contain a domain similar to the C-terminal domain of glutathione S-transferase (AllFam:AF010).

Allergens from this family

Pen c 24, a minor allergen from Penicillium citrinum was identified as EF-1β [2].



  1. Le Sourd F, Boulben S, Le Bouffant R, Cormier P, Morales J, Belle R, Mulner-Lorillon O:
    eEF1B: At the dawn of the 21st century.
    Biochim Biophys Acta 2006, 1759, 13-31. [PubMed] [Full Text]
  2. Tang RB, Chen YS, Chou H, Lee SS, Tai HY, Shen HD:
    cDNA cloning and immunologic characterization of a novel EF-1beta allergen from Penicillium citrinum.
    Allergy 2005, 60, 366-71. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00736 EF-1 guanine nucleotide exchange domain -
PF10587 Eukaryotic elongation factor 1 beta central acidic region -

Links to Wikipedia


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