Eukaryotic elongation factor 1 (EF-1) is responsible for the GTP-dependent binding of aminoacyl-tRNAs to the ribosomes. It is composed of four subunits. The β and δ chains are highly similar proteins that both stimulate the exchange of GDP bound to the α chain for GTP . On their N-termini, they contain a domain similar to the C-terminal domain of glutathione S-transferase (AllFam:AF010).
Pen c 24, a minor allergen from Penicillium citrinum was identified as EF-1β .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00736||EF-1 guanine nucleotide exchange domain||-|
|PF10587||Eukaryotic elongation factor 1 beta central acidic region||-|
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