AF013: Kazal-type serine protease inhibitor

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The family of Kazal inhibitors, which inhibit serine proteases (such as trypsin and elastase), includes pancreatic secretory trypsin inhibitor, avian ovomucoid, acrosin inhibitor, and elastase inhibitor. These proteins contain between 1 and 7 Kazal-type inhibitor repeats.

Allergens from this family

Ovomucoid from hen's egg (Gal d 1) is a major egg allergen [1]. Gal d 1-specific IgE was shown to cross-react with homologous proteins from other bird species [2].



  1. Mine Y, Zhang JW:
    Comparative studies on antigenicity and allergenicity of native and denatured egg white proteins.
    J Agric Food Chem 2002, 50, 2679-83. [PubMed]
  2. Langeland T:
    A clinical and immunological study of allergy to hen's egg white. VI. Occurrence of proteins cross-reacting with allergens in hen's egg white as studied in egg white from turkey, duck, goose, seagull, and in hen egg yolk, and hen and chicken sera and flesh.
    Allergy 1983, 38, 399-412. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00050 Kazal-type serine protease inhibitor domain CL0005 Kazal like domain

Links to Wikipedia


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