AF013: Kazal-type serine protease inhibitor
The family of Kazal inhibitors, which inhibit serine proteases (such as trypsin and elastase), includes pancreatic secretory trypsin inhibitor, avian ovomucoid, acrosin inhibitor, and elastase inhibitor. These proteins contain between 1 and 7 Kazal-type inhibitor repeats.
Allergens from this family
Ovomucoid from hen's egg (Gal d 1) is a major egg allergen . Gal d 1-specific IgE was shown to cross-react with homologous proteins from other bird species .
Comparative studies on antigenicity and allergenicity of native and denatured egg white proteins.
J Agric Food Chem 2002, 50, 2679-83. [PubMed]
A clinical and immunological study of allergy to hen's egg white. VI. Occurrence of proteins cross-reacting with allergens in hen's egg white as studied in egg white from turkey, duck, goose, seagull, and in hen egg yolk, and hen and chicken sera and flesh.
Allergy 1983, 38, 399-412. [PubMed]
Links to Pfam
Family-defining Pfam domains (at least one of these domains is present in each family member):
Kazal-type serine protease inhibitor domain
Kazal like domain
Links to Wikipedia
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