AF014: Lactate/malate dehydrogenase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family contains L-lactate dehydrogenases, malate dehydrogenases and L-2-hydroxyisocaproate dehydrogenases. The N-terminal, NAD-binding domain adopts a Rossmann fold [1].

Allergens from this family

Mala f 4, a major allergen from the yeast Malassezia furfur, is a malate dehydrogenase [2].



  1. Madern D:
    Molecular evolution within the L-malate and L-lactate dehydrogenase super-family.
    J Mol Evol 2002, 54, 825-40. [PubMed] [Full Text]
  2. Onishi Y, Kuroda M, Yasueda H, Saito A, Sono-Koyama E, Tunasawa S, Hashida-Okado T, Yagihara T, Uchida K, Yamaguchi H, Akiyama K, Kato I, Takesako K:
    Two-dimensional electrophoresis of Malassezia allergens for atopic dermatitis and isolation of Mal f 4 homologs with mitochondrial malate dehydrogenase.
    Eur J Biochem 1999, 261, 148-54. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00056 lactate/malate dehydrogenase, NAD binding domain CL0063 FAD/NAD(P)-binding Rossmann fold Superfamily
PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain CL0341 LDH C-terminal domain-like superfamily

Links to Wikipedia


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