AF015: Lipocalin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids [1]. The family also contains the enzyme prostaglandin D synthase. Lipocalins fold into an eight-stranded anti-parallel β-barrel.

Allergens from this family

Allergens from this protein family are:



  1. Grzyb J, Latowski D, Strzalka K:
    Lipocalins - a family portrait.
    J Plant Physiol 2006, 163, 895-915. [PubMed] [Full Text]
  2. Kontopidis G, Holt C, Sawyer L:
    Invited review: beta-lactoglobulin: binding properties, structure, and function.
    J Dairy Sci 2004, 87, 785-96. [PubMed] [Full Text]
  3. Wal JM:
    Bovine milk allergenicity.
    Ann Allergy Asthma Immunol 2004, 93, S2-11. [PubMed]
  4. Restani P, Gaiaschi A, Plebani A, Beretta B, Cavagni G, Fiocchi A, Poiesi C, Velona T, Ugazio AG, Galli CL:
    Cross-reactivity between milk proteins from different animal species.
    Clin Exp Allergy 1999, 29, 997-1004. [PubMed]
  5. Virtanen T, Kinnunen T, Rytkonen-Nissinen M:
    Mammalian lipocalin allergens--insights into their enigmatic allergenicity.
    Clin Exp Allergy 2012, 42, 494-504. [PubMed] [Full Text]
  6. Thomas WR, Smith WA, Hales BJ, Mills KL, O'Brien RM:
    Characterization and immunobiology of house dust mite allergens.
    Int Arch Allergy Immunol 2002, 129, 1-18. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00061 Lipocalin / cytosolic fatty-acid binding protein family CL0116 Calycin superfamily
PF08212 Lipocalin-like domain CL0116 Calycin superfamily

Links to Wikipedia


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