The glycoside hydrolase family 22 comprises enzymes with two known activities: lysozyme type C and α-lactalbumins [1]. α-Lactalbumin is the regulatory subunit of lactose synthase that changes the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Members of this family fold into a multi-domain, mixed alpha and beta fold that contains four conserved disulfide bonds.
Allergen from this family include α-lactalbumin from cow's milk (Bos d 4) [2] and hen's egg lysozyme (Gal d 4).
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF00062 | C-type lysozyme/alpha-lactalbumin family | CL0037 | Lysozyme-like superfamily |
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