AF016: C-type lysozyme/alpha-lactalbumin family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The glycoside hydrolase family 22 comprises enzymes with two known activities: lysozyme type C and α-lactalbumins [1]. α-Lactalbumin is the regulatory subunit of lactose synthase that changes the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Members of this family fold into a multi-domain, mixed alpha and beta fold that contains four conserved disulfide bonds.

Allergens from this family

Allergen from this family include α-lactalbumin from cow's milk (Bos d 4) [2] and hen's egg lysozyme (Gal d 4).



  1. Qasba PK, Kumar S:
    Molecular divergence of lysozymes and alpha-lactalbumin.
    Crit Rev Biochem Mol Biol 1997, 32, 255-306. [PubMed] [Full Text]
  2. Wal JM:
    Bovine milk allergenicity.
    Ann Allergy Asthma Immunol 2004, 93, S2-11. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00062 C-type lysozyme/alpha-lactalbumin family CL0037 Lysozyme-like superfamily

Links to Wikipedia


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