AF018: Serpin serine protease inhibitor

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Serpins are irreversible serine protease inhibitors active against S1, S8 and C14 peptidases [1]. Their common structure is a multi-domain fold containing a bundle of 8 or 9 α-helices and a β-sandwich formed by 3 β-sheets.

Allergens from this family

Allergens from this family include hen's egg ovalbumin (Gal d 2) and Z4 from barley, a protein causing allergic reactions to beer [2, 3].



  1. Law RH, Zhang Q, McGowan S, Buckle AM, Silverman GA, Wong W, Rosado CJ, Langendorf CG, Pike RN, Bird PI, Whisstock JC:
    An overview of the serpin superfamily.
    Genome Biol 2006, 7, 216. [PubMed] [Full Text]
  2. Mine Y, Zhang JW:
    Comparative studies on antigenicity and allergenicity of native and denatured egg white proteins.
    J Agric Food Chem 2002, 50, 2679-83. [PubMed]
  3. Garcia-Casado G, Crespo JF, Rodriguez J, Salcedo G:
    Isolation and characterization of barley lipid transfer protein and protein Z as beer allergens.
    J Allergy Clin Immunol 2001, 108, 647-9. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00079 Serpin (serine protease inhibitor) -

Links to Wikipedia


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