AF020: Fe/Mn superoxide dismutase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The function of superoxide dismutase (SOD) is to destroy the radicals that are normally produced within cells and are toxic to biological systems by catalysing the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Fe/Mn-binding family is one.

Allergens from this family

Mn-binding superoxide dismutases from plants and fungi were identified as cross-reactive allergens [1, 2].



  1. Wagner S, Sowka S, Mayer C, Crameri R, Focke M, Kurup VP, Scheiner O, Breiteneder H:
    Identification of a Hevea brasiliensis latex manganese superoxide dismutase (Hev b 10) as a cross-reactive allergen.
    Int Arch Allergy Immunol 2001, 125, 120-7. [PubMed] [Full Text]
  2. Fluckiger S, Scapozza L, Mayer C, Blaser K, Folkers G, Crameri R:
    Immunological and structural analysis of IgE-mediated cross-reactivity between manganese superoxide dismutases.
    Int Arch Allergy Immunol 2002, 128, 292-303. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00081 Iron/manganese superoxide dismutases, alpha-hairpin domain -
PF02777 Iron/manganese superoxide dismutases, C-terminal domain -

Links to Wikipedia


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