AF024: Trypsin-like serine protease

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This group of serine proteases belongs to the MEROPS peptidase families S1 (chymotrypsin family, clan PA(S)). The chymotrypsin family is almost totally confined to animals. The enzymes are either secreted directly or packaged into vesicles for regulated secretion [1].

Allergens from this family

Allergens from the trypsin family constitute three groups of mite and cockroach allergens [2]. Group 3 mite allergens are trypsins and are major constituents of mite faeces. Trypsins are also found in cockroaches [3]. Group 6 mite allergens are chymotrypsins and show no cross-reactivity with group 3 allergens. Group 9 allergens exhibit a collagenase activity. Trypsin-like allergens are also found in insect venoms [4]. The dog allergen Can f 5 is an arginine esterase that belongs to this family.



  1. Rawlings ND, Barrett AJ:
    Families of serine peptidases.
    Methods Enzymol 1994, 244, 19-61. [PubMed]
  2. Thomas WR, Smith WA, Hales BJ, Mills KL, O'Brien RM:
    Characterization and immunobiology of house dust mite allergens.
    Int Arch Allergy Immunol 2002, 129, 1-18. [PubMed] [Full Text]
  3. Ock MS, Kim BJ, Kim SM, Byun KH:
    Cloning and expression of trypsin-encoding cDNA from Blattella germanica and its possibility as an allergen.
    Korean J Parasitol 2005, 43, 101-10. [PubMed]
  4. Winningham KM, Fitch CD, Schmidt M, Hoffman DR:
    Hymenoptera venom protease allergens.
    J Allergy Clin Immunol 2004, 114, 928-33. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00089 Trypsin CL0124 Peptidase clan PA

Links to Wikipedia


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