AF025: Tubulin/FtsZ family
Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division, while tubulin is the major component of microtubules. Members of both families are GTPases .
Allergens from this family
Tubulins from house dust and storage mites were identified as minor allergens [2, 3, 4].
Tubulin and FtsZ form a distinct family of GTPases.
Nat Struct Biol 1998, 5, 451-8. [PubMed]
Cloning and characterisation of two IgE-binding proteins, homologous to tropomyosin and alpha-tubulin, from the mite Lepidoglyphus destructor.
Int Arch Allergy Immunol 2003, 130, 258-65. [PubMed] [Full Text]
Immunoglobulin E binding reactivity of a recombinant allergen homologous to alpha-Tubulin from Tyrophagus putrescentiae.
Clin Diagn Lab Immunol 2005, 12, 1451-4. [PubMed] [Full Text]
Identification of alpha-tubulin, Der f 33, as a novel allergen from Dermatophagoides farinae.
Immunobiology 2016, 221, 911-7. [PubMed] [Full Text]
Links to Pfam
Family-defining Pfam domains (at least one of these domains is present in each family member):
Tubulin/FtsZ family, GTPase domain
Tubulin nucleotide-binding domain-like, GTPase
Tubulin C-terminal domain
Tubulin, FtsZ and Misato and their C-termini,
Links to Wikipedia
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