AF025: Tubulin/FtsZ family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division, while tubulin is the major component of microtubules. Members of both families are GTPases [1].

Allergens from this family

Tubulins from house dust and storage mites were identified as minor allergens [2, 3, 4].



  1. Nogales E, Downing KH, Amos LA, Lowe J:
    Tubulin and FtsZ form a distinct family of GTPases.
    Nat Struct Biol 1998, 5, 451-8. [PubMed]
  2. Saarne T, Kaiser L, Rasool O, Huecas S, van Hage-Hamsten M, Gafvelin G:
    Cloning and characterisation of two IgE-binding proteins, homologous to tropomyosin and alpha-tubulin, from the mite Lepidoglyphus destructor.
    Int Arch Allergy Immunol 2003, 130, 258-65. [PubMed] [Full Text]
  3. Jeong KY, Lee H, Lee JS, Lee J, Lee IY, Ree HI, Hong CS, Park JW, Yong TS:
    Immunoglobulin E binding reactivity of a recombinant allergen homologous to alpha-Tubulin from Tyrophagus putrescentiae.
    Clin Diagn Lab Immunol 2005, 12, 1451-4. [PubMed] [Full Text]
  4. Wang H, Lin J, Liu X, Liang Z, Yang P, Ran P, Liu Z:
    Identification of alpha-tubulin, Der f 33, as a novel allergen from Dermatophagoides farinae.
    Immunobiology 2016, 221, 911-7. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00091 Tubulin/FtsZ family, GTPase domain CL0566 Tubulin nucleotide-binding domain-like, GTPase
PF03953 Tubulin C-terminal domain CL0442 Tubulin, FtsZ and Misato and their C-termini,

Links to Wikipedia


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