AF026: Pectin methylesterase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Pectin methylesterases (or pectinesterases) catalyse the de-esterification of pectin, one of the main components of the plant cell wall, into pectate and methanol. In plants, pectin methylesterases play an important role in cell wall metabolism during fruit ripening. In bacterial and fungal plant pathogens, pectin methylesterases are involved in maceration and soft-rotting of plant tissue [1].

Allergens from this family

Pectin methylesterases were described as allergens in pollen and plant foods. Sal k 1 from Russian thistle (Salsola kali) pollen was shown to be a major allergen not present in pollen of the related species Chenopondium album [2]. A minor allergen from birch pollen also belongs to this family [3]. Moreover, Act d 7 is a minor allergen from kiwi fruit.



  1. Jolie RP, Duvetter T, Van Loey AM, Hendrickx ME:
    Pectin methylesterase and its proteinaceous inhibitor: a review.
    Carbohydr Res 2010, 345, 2583-95. [PubMed] [Full Text]
  2. Barderas R, Garcia-Selles J, Salamanca G, Colas C, Barber D, Rodriguez R, Villalba M:
    A pectin methylesterase as an allergenic marker for the sensitization to Russian thistle (Salsola kali) pollen.
    Clin Exp Allergy 2007, 37, 1111-9. [PubMed] [Full Text]
  3. Mahler V, Fischer S, Heiss S, Duchene M, Kraft D, Valenta R:
    cDna cloning and characterization of a cross-reactive birch pollen allergen: identification as a pectin esterase.
    Int Arch Allergy Immunol 2001, 124, 64-6. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01095 Pectinesterase CL0268 Pectate lyase-like beta helix

Links to Wikipedia


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