AF027: Cysteine-rich trypsin inhibitor-like domain

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds.

Allergens from this family

Allergens that contain this domain are the bee venom allergen Api m 6 [1] and the minor Anisakis simplex allergen Ani s 6 [2].



  1. Kettner A, Hughes GJ, Frutiger S, Astori M, Roggero M, Spertini F, Corradin G:
    Api m 6: a new bee venom allergen.
    J Allergy Clin Immunol 2001, 107, 914-20. [PubMed] [Full Text]
  2. Kobayashi Y, Ishizaki S, Shimakura K, Nagashima Y, Shiomi K:
    Molecular cloning and expression of two new allergens from Anisakis simplex.
    Parasitol Res 2007, 100, 1233-41. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01826 Trypsin Inhibitor like cysteine rich domain -


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