AF028: Short-chain dehydrogenase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The short-chain dehydrogenase/reductase family (SDR) is a very large family of enzymes, most of which are known to be NAD or NADP-dependent oxidoreductases [1].

Allergens from this family

The fungal allergens Alt a 8 from Alternaria alternata and Cla h 8 from Cladosporium herbarum are mannitol dehydrogenases [2].



  1. Jornvall H, Persson B, Krook M, Atrian S, Gonzalez-Duarte R, Jeffery J, Ghosh D:
    Short-chain dehydrogenases/reductases (SDR).
    Biochemistry 1995, 34, 6003-13. [PubMed]
  2. Simon-Nobbe B, Denk U, Schneider PB, Radauer C, Teige M, Crameri R, Hawranek T, Lang R, Richter K, Schmid-Grendelmeier P, Nobbe S, Hartl A, Breitenbach M:
    NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarum.
    J Biol Chem 2006, 281, 16354-60. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00106 short chain dehydrogenase CL0063 FAD/NAD(P)-binding Rossmann fold Superfamily
PF13561 Enoyl-(Acyl carrier protein) reductase CL0063 FAD/NAD(P)-binding Rossmann fold Superfamily

Links to Wikipedia


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