Triosephosphate isomerase (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production. It is a dimer of identical subunits, each of which is made up of about 250 amino acid residues and folds into an eight-stranded β-barrel (the TIM barrel), a wide-spread fold found in many enzyme families .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00121||Triosephosphate isomerase||CL0036||Common phosphate binding-site TIM barrel superfamily|
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