AF034: Legume lectin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Legume lectins are one of the largest lectin families. They resemble each other in their physicochemical properties although they differ in their carbohydrate specificities. Legume lectins consist of two or four subunits with molecular masses of 30 kDa each subunit having one carbohydrate-binding site. The interaction with sugars requires tightly bound calcium and manganese ions. The exact function of legume lectins is not known but they may be involved in the attachment of nitrogen-fixing bacteria and in the protection against pathogens [1].

Allergens from this family

Peanut agglutinin was identified as a minor allergen [2].



  1. Ng TB:
    Antifungal proteins and peptides of leguminous and non-leguminous origins.
    Peptides 2004, 25, 1215-22. [PubMed] [Full Text]
  2. Burks AW, Cockrell G, Connaughton C, Guin J, Allen W, Helm RM:
    Identification of peanut agglutinin and soybean trypsin inhibitor as minor legume allergens.
    Int Arch Allergy Immunol 1994, 105, 143-9. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00139 Legume lectin domain CL0004 Concanavalin-like lectin/glucanase superfamily

Links to Wikipedia


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